Studium vlivu kombinace mukoadhezivních polymerů na chování matricových systémů v prostředí žaludku

• Main Author: Johnová, Karolína
• Other Authors: Vraníková, Barbora
• Format: Dissertation
• Language: Czech
• Published: 2021
• Online Access: http://www.nusl.cz/ntk/nusl-446273

Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Mentor: PharmDr. Barbora Vraníková, Ph.D. Consultant: Mgr. Chiazor Ugo Ogadah Student: Karolína Johnová Title of Thesis: Effect of combination of mucoadhesive polymers on the behaviour of matrix tablets in the gastric environment Colon-targeted drug delivery plays a significant role in the pharmacotherapy of local diseases situated in the large intestine (colorectal cancer, inflammatory bowel diseases etc.). In terms of sustained drug release, such formulations carrying the active substance must be resistant to the acidic environment of the upper gastrointestinal tract. In addition, an enhanced therapeutic efficacy may be achieved by prolonging the residence time of the formulation at the absorption site by means of mucoadhesive drug delivery systems. For these reasons, the presented preformulation study investigates the behaviour of matrix tablets based on mucoadhesive polymers in the gastric environment. Knowledge of the system behaviour in acidic pH is important as the surrounding of an inflammatory colon may be lower in comparison to the physiological conditions. The selected polymers, guar gum (GK) and hydroxypropyl methylcellulose K15M (HPMC K15M) were used separately or combined in ratios...