Sprejové sušení suspenze léčiva v roztoku chitosanu

• Main Author: Bartoňová, Eva
• Other Authors: Svačinová, Petra
• Format: Dissertation
• Language: Czech
• Published: 2021
• Online Access: http://www.nusl.cz/ntk/nusl-446524

2 ABSTRACT Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: PharmDr. Petra Svačinová, Ph.D. Student: Eva Bartoňová Title of Thesis: Spray drying of a suspension of the drug in a solution of chitosan During spray drying a liquid solution, suspension, or emulsion is converted to solid particles by means of a hot drying medium. The set drying parameters can affect the properties of the resulting particles. This work deals with the preparation of particles from a suspension of meloxicam in a solution of chitosan and the influence of the drying parameters and the concentration of this solution on the properties of the particles. The concentration of the solution was 0,5 %, 1 %, 1,5 % and 2 %. The inlet temperature was set at 170, 190 and 210 řC. The 2% sample was not dried due to high viscosity and nozzle clogging. The particles were evaluated by optical microscopy, scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and a dissolution test was used to evaluate the drug release from the particles. Two measurements were performed by DSC, the first M1 after drying the particles and the second M2 after 6 months. The resulting particles were spherical and irregular in shape and formed clumps. The particle shape was not affected by...