UHPLC-MS/MS analýza vybraných léčiv v biologickém materiálu
Dexrazoxane (DEX), a bisdioxopiperazine derivative, is the only clinically used drug effective against anthracycline-induced cardiotoxicity. First studies indicated that DEX is a pro-drug bioactivated in cardiomyocytes by enzymatic hydrolysis of piperazine rings to its active metabolite - ADR-925. H...
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| Format: | Dissertation |
| Language: | Czech |
| Published: |
2021
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| Online Access: | http://www.nusl.cz/ntk/nusl-446563 |