Tumor infiltrující lymfocyty jako prognostický faktor prognózy kolorektálního karcinomu po radikální chirurgické léčbě

• Main Author: Novák, Petr
• Other Authors: Vodička, Josef
• Format: Doctoral Thesis
• Language: Czech
• Published: 2015
• Online Access: http://www.nusl.cz/ntk/nusl-450486

Novák P.: Tumor infiltrating lymphocytes as prognostic factor of colorectal cancer after radical surgical treatment Background: Colorectal cancer (CRC) belongs among the most frequent malignant diseases and represents worldwide problem. Czech Republic has one of the highest incidence of CRC. The fight against this disease is kept in many lines as preventive, surgical and oncological treatment and very important part is also the estimation of prognosis and suggestion of individual treatment. Aim: The aim of this study was to analyze the relation of contemporary clinical and histopathological factors and tumor infiltrating lymphocytes, dendritic and natural killer cells. The next aim was to differentiate the patients with high risk of shortened overal survival and tendency to early recurrence of CRC after radical surgical treatment. Methods: We analyzed the group of 150 patients (93 men, 57 women) that were operated on at the Department of Surgery of Teaching Hospital in Pilsen between 2004 and 2007. The important condition for inclusion into the study was radical operation. We excluded patients with any disease that could influence immunological reactivity. We examined endovascular, endolymphatic, perineural infiltration by tumor cells (0 - none, 1 positive). Infiltrations of tumor by lymphatic cells...