Anatomie jater prasete domácího jako modelového orgánu v biomedicíně
Introduction: This dissertation summarizes our research published in seven articles where we described both the ways of utilization of porcine liver in biomedical research and the basic morphometric parameters of hepatocytes and liver connective tissue useful in experimental surgery followed by live...
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2021
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Online Access: | http://www.nusl.cz/ntk/nusl-451956 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-4519562021-10-11T05:10:21Z Anatomie jater prasete domácího jako modelového orgánu v biomedicíně Porcine Liver Anatomy Applied in Biomedicine Mik, Patrik Eberlová, Lada Kachlík, David Stingl, Josef Introduction: This dissertation summarizes our research published in seven articles where we described both the ways of utilization of porcine liver in biomedical research and the basic morphometric parameters of hepatocytes and liver connective tissue useful in experimental surgery followed by liver regeneration experiments. We set off with the description of anatomical concepts of human liver applied to clinical investigation followed by summary of porcine liver morphology with special stress on its potential clinical utilization. The studies in experimental surgery followed by liver regeneration where the porcine liver model proved its utility, reveals that the distribution of portal blood to the liver parenchyma, the number and the volume of mononuclear and binuclear hepatocytes, and the amount and the distribution of liver connective tissue being among the most useful ones. Methods: For the mapping of portal vein branching we used µCT scans of porcine liver corrosion casts, and both the quantitative parameters of the hepatocytes and of the connective tissue were evaluated on systematic uniform random paraffin-embedded samples that were harvested from three different regions of interest (ROI) of liver parenchyma (peripheral, paracaval and paraportal). For the quantification, we followed... 2021 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-451956 cze info:eu-repo/semantics/restrictedAccess |
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Czech |
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Doctoral Thesis |
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NDLTD |
description |
Introduction: This dissertation summarizes our research published in seven articles where we described both the ways of utilization of porcine liver in biomedical research and the basic morphometric parameters of hepatocytes and liver connective tissue useful in experimental surgery followed by liver regeneration experiments. We set off with the description of anatomical concepts of human liver applied to clinical investigation followed by summary of porcine liver morphology with special stress on its potential clinical utilization. The studies in experimental surgery followed by liver regeneration where the porcine liver model proved its utility, reveals that the distribution of portal blood to the liver parenchyma, the number and the volume of mononuclear and binuclear hepatocytes, and the amount and the distribution of liver connective tissue being among the most useful ones. Methods: For the mapping of portal vein branching we used µCT scans of porcine liver corrosion casts, and both the quantitative parameters of the hepatocytes and of the connective tissue were evaluated on systematic uniform random paraffin-embedded samples that were harvested from three different regions of interest (ROI) of liver parenchyma (peripheral, paracaval and paraportal). For the quantification, we followed... |
author2 |
Eberlová, Lada |
author_facet |
Eberlová, Lada Mik, Patrik |
author |
Mik, Patrik |
spellingShingle |
Mik, Patrik Anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
author_sort |
Mik, Patrik |
title |
Anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
title_short |
Anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
title_full |
Anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
title_fullStr |
Anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
title_full_unstemmed |
Anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
title_sort |
anatomie jater prasete domácího jako modelového orgánu v biomedicíně |
publishDate |
2021 |
url |
http://www.nusl.cz/ntk/nusl-451956 |
work_keys_str_mv |
AT mikpatrik anatomiejaterprasetedomacihojakomodelovehoorganuvbiomedicine AT mikpatrik porcineliveranatomyappliedinbiomedicine |
_version_ |
1719488867381280768 |