Synthesis of charged cyclodextrin highly soluble in organic solvents for enantiomer separations in capillary electrophoresis
Synthesis of charged cyclodextrin highly soluble in organic solvents was made by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl- 6-O-sulfo)-ò-CD (Na7HDMS) with tetrabutylammonium (TBA+), to produce TBA7HDMS. The same ion exchange was used to synthesize the TBA salts of the...
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| Format: | Others |
| Language: | en_US |
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Texas A&M University
2006
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| Online Access: | http://hdl.handle.net/1969.1/4211 |
| Summary: | Synthesis of charged cyclodextrin highly soluble in organic solvents was
made by exchanging the inorganic counter ion (Na+) of heptakis (2,3-di-Omethyl-
6-O-sulfo)-ò-CD (Na7HDMS) with tetrabutylammonium (TBA+), to
produce TBA7HDMS. The same ion exchange was used to synthesize the TBA
salts of the analogous CDs TBA6HxDMS and TBA8ODMS. Indirect-UV
detection capillary electrophoresis (CE) and 1H NMR were used as the
characterization methods.
Separations of thirteen pharmaceuticals were made using TBA7HDMS as
the chiral resolving agent in aqueous CE. On the other hand, a set of twenty
pharmaceuticals was used for the enantiomer separations in non-aqueous CE
(NACE). Comparison between the results obtained with TBA7HDMS in aqueous
and non-aqueous CE were made. In addition, comparison between the results
obtained with TBA7HDMS and Na7HDMS in aqueous and non-aqueous CE were
made as well. |
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