Substitution de la liaison amide par un triazole 1,4- disubstitué dans le but d’étudier l’impact de ce remplacement sur la structure secondaire et l’activité biologique de peptides

Substitution de la liaison amide par un triazole 1,4- disubstitué dans le but d’étudier l’impact de ce remplacement sur la structure secondaire et l’activité biologique de peptides

La réaction de cycloaddition entre un azoture et un alcyne catalysée par le cuivre (I) (CuAAC) pour former un 1,2,3-triazole 1,4-disubstitué est très utilisée dans de nombreux domaines de la chimie. Cette réaction a très vite été utilisée en synthèse peptidique notamment du fait du caractère isostèr...

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Bibliographic Details
Main Author:	Ben Haj Salah, Khoubaib
Other Authors:	Montpellier
Language:	fr en
Published:	2015
Subjects:	Peptaibols Tamandarin B Structure secondaire CuAAC 1.2.3-Triazole Peptidomimétique Secondary structure Peptidomics
Online Access:	http://www.theses.fr/2015MONTS003/document

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