Variants rares et analyse d'exomes : application à la maladie d'Alzheimer du sujet jeune

Variants rares et analyse d'exomes : application à la maladie d'Alzheimer du sujet jeune

L’avènement du séquençage haut débit permet actuellement d’étudier et d’analyser la part de lacomposante génétique des maladies complexes médiée par les variants rares. Cependant, leurinterprétation représente un défi majeur. En effet, le séquençage de milliers d’exomes et degénomes a révélé la comp...

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Bibliographic Details
Main Author:	Le Guennec, Kilan
Other Authors:	Normandie
Language:	fr
Published:	2017
Subjects:	Séquençage haut-débit Exome Etudes d'association Maladie d'Alzheimer du sujet jeune ABCA7 CNV MAPT 17q21.31 PSEN1 Next-generation sequencing Association study Early-onset Alzheimer Disease 616.831
Online Access:	http://www.theses.fr/2017NORMR148/document

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