Feasibility of intra-articular adeno-associated virus-mediated proteoglycan-4 gene therapy to prevent osteoarthritis
Lubricin, or proteoglycan 4 (PRG4), is a secreted, glycosylated protein that binds to cartilage surfaces, which functions as a boundary lubricant. The loss of lubricin from cartilage is identified as a major pathogenic factor in post-traumatic osteoarthritis (PTOA) that has now been the aim of thera...
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| Format: | Others |
| Language: | English |
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University of Iowa
2015
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| Online Access: | https://ir.uiowa.edu/etd/1836 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=5893&context=etd |