Reference Compensation for Localized Surface-Plasmon Resonance Sensors
Noble metal nanoparticles supporting localized surface plasmon resonances (LSPR) have been extensively investigated for label free detection of various biological and chemical interactions. When compared to other optical sensing techniques, LSPR sensors offer label-free detection of biomolecular int...
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ndltd-uky.edu-oai-uknowledge.uky.edu-ece_etds-10432015-04-11T05:04:01Z Reference Compensation for Localized Surface-Plasmon Resonance Sensors Nehru, Neha Noble metal nanoparticles supporting localized surface plasmon resonances (LSPR) have been extensively investigated for label free detection of various biological and chemical interactions. When compared to other optical sensing techniques, LSPR sensors offer label-free detection of biomolecular interactions in localized sensing volume solutions. However, these sensors also suffer from a major disadvantage – LSPR sensors remain highly susceptible to interference because they respond to both solution refractive index change and non-specific binding as well as specific binding of the target analyte. These interactions can severely compromise the measurement of the target analyte in a complex unknown media and hence limit the applicability and impact of the sensor. In spite of the extensive amount of work done in this field, there has been a clear absence of efforts to make LSPR sensors immune to interfering effects. The work presented in this document investigates, both experimentally and numerically, dual- and tri-mode LSPR sensors that utilize the multiple surface plasmon modes of gold nanostructures to distinguish target analyte from interfering bulk and non-specific binding effects. Finally, a series of biosensing experiments are performed to examine various regeneration assays for LSPR sensors built on indium tin oxide coated glass substrate. 2014-01-01T08:00:00Z text application/pdf http://uknowledge.uky.edu/ece_etds/41 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1043&context=ece_etds Theses and Dissertations--Electrical and Computer Engineering UKnowledge Localized Surface Plasmon Resonance Biosensor Optical sensing Plasmonics Interference Compensation Biomedical Electromagnetics and photonics Nanoscience and Nanotechnology Nanotechnology fabrication Optics |
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Localized Surface Plasmon Resonance Biosensor Optical sensing Plasmonics Interference Compensation Biomedical Electromagnetics and photonics Nanoscience and Nanotechnology Nanotechnology fabrication Optics |
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Localized Surface Plasmon Resonance Biosensor Optical sensing Plasmonics Interference Compensation Biomedical Electromagnetics and photonics Nanoscience and Nanotechnology Nanotechnology fabrication Optics Nehru, Neha Reference Compensation for Localized Surface-Plasmon Resonance Sensors |
description |
Noble metal nanoparticles supporting localized surface plasmon resonances (LSPR) have been extensively investigated for label free detection of various biological and chemical interactions. When compared to other optical sensing techniques, LSPR sensors offer label-free detection of biomolecular interactions in localized sensing volume solutions. However, these sensors also suffer from a major disadvantage – LSPR sensors remain highly susceptible to interference because they respond to both solution refractive index change and non-specific binding as well as specific binding of the target analyte. These interactions can severely compromise the measurement of the target analyte in a complex unknown media and hence limit the applicability and impact of the sensor. In spite of the extensive amount of work done in this field, there has been a clear absence of efforts to make LSPR sensors immune to interfering effects. The work presented in this document investigates, both experimentally and numerically, dual- and tri-mode LSPR sensors that utilize the multiple surface plasmon modes of gold nanostructures to distinguish target analyte from interfering bulk and non-specific binding effects. Finally, a series of biosensing experiments are performed to examine various regeneration assays for LSPR sensors built on indium tin oxide coated glass substrate. |
author |
Nehru, Neha |
author_facet |
Nehru, Neha |
author_sort |
Nehru, Neha |
title |
Reference Compensation for Localized Surface-Plasmon Resonance Sensors |
title_short |
Reference Compensation for Localized Surface-Plasmon Resonance Sensors |
title_full |
Reference Compensation for Localized Surface-Plasmon Resonance Sensors |
title_fullStr |
Reference Compensation for Localized Surface-Plasmon Resonance Sensors |
title_full_unstemmed |
Reference Compensation for Localized Surface-Plasmon Resonance Sensors |
title_sort |
reference compensation for localized surface-plasmon resonance sensors |
publisher |
UKnowledge |
publishDate |
2014 |
url |
http://uknowledge.uky.edu/ece_etds/41 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1043&context=ece_etds |
work_keys_str_mv |
AT nehruneha referencecompensationforlocalizedsurfaceplasmonresonancesensors |
_version_ |
1716800730260570112 |