Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release.
Tissue response to PNIPAM and HPC nanoparticles has been studied by implantation method. The results suggest that both PNIAPM and HPC nanoparticles possess good biocompatibility and they may serve as a good carrier for the applications of controlled delivery. Rheological properties of dispersions of...
Main Author: | |
---|---|
Other Authors: | |
Format: | Others |
Language: | English |
Published: |
University of North Texas
2009
|
Subjects: | |
Online Access: | https://digital.library.unt.edu/ark:/67531/metadc11001/ |
id |
ndltd-unt.edu-info-ark-67531-metadc11001 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-unt.edu-info-ark-67531-metadc110012017-03-17T08:36:12Z Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. Zhou, Jun Microgel drug release colloidal crystal self-assemble Microencapsulation. Drugs -- Controlled release. Crystallization. Polymer colloids. Tissue response to PNIPAM and HPC nanoparticles has been studied by implantation method. The results suggest that both PNIAPM and HPC nanoparticles possess good biocompatibility and they may serve as a good carrier for the applications of controlled delivery. Rheological properties of dispersions of IPN microgels composed of PNIPAM and PAAc have been studied. It is found that the IPN microgel dispersion can undergo a sol-gel transition at temperature above 33°C. In vivo drug release experiments suggest that the gelation procedure creates a diffusion barrier and thus leads to slow release. An emulsion method has been used to grow columnar crystals by mixing PNIPAM microgel dispersions with organic solvents. Effect of both temperature and microgel concentration on formation of columnar crystals has been studied. PNIPAM-co-NMA microgels have been used for the fabrication of crystalline hydrogel films by self-crosslinking microgels. The hydrogel film exhibits an iridescent. The thermally responsive properties and mechanical properties of this film have been studied. Melting temperature (Tm) of colloidal crystals self-assembled with PNIPAM-co-AAc microgels has been investigated as a function of pH, salt concentration and microgel concentration. It is revealed that Tm increases as pH value increases; Tm decreases with increase of salt concentration; Tm increases as microgel concentration increases. Phase behavior of PNIPAM-co-HEAc microgel dispersions has been investigated. It is observed that these microgel dispersions exhibit liquid, crystal, and glass phase. As microgel size increases, crystal phase shifts to low concentration range. As temperature increases, crystal phase shifts to high concentration ranges. These colloidal crystals can be stabilized by NaOH-induced gelation. Effect of NaOH concentration on formation of physical gelation has been investigated. University of North Texas Hu, Zhibing D'Souza, Nandika A. Bouanani, Mohamed El Reidy, Richard F. 2009-08 Thesis or Dissertation Text oclc: 492132470 untcat: b3808498 https://digital.library.unt.edu/ark:/67531/metadc11001/ ark: ark:/67531/metadc11001 English Public Copyright Zhou, Jun Copyright is held by the author, unless otherwise noted. All rights reserved. |
collection |
NDLTD |
language |
English |
format |
Others
|
sources |
NDLTD |
topic |
Microgel drug release colloidal crystal self-assemble Microencapsulation. Drugs -- Controlled release. Crystallization. Polymer colloids. |
spellingShingle |
Microgel drug release colloidal crystal self-assemble Microencapsulation. Drugs -- Controlled release. Crystallization. Polymer colloids. Zhou, Jun Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
description |
Tissue response to PNIPAM and HPC nanoparticles has been studied by implantation method. The results suggest that both PNIAPM and HPC nanoparticles possess good biocompatibility and they may serve as a good carrier for the applications of controlled delivery. Rheological properties of dispersions of IPN microgels composed of PNIPAM and PAAc have been studied. It is found that the IPN microgel dispersion can undergo a sol-gel transition at temperature above 33°C. In vivo drug release experiments suggest that the gelation procedure creates a diffusion barrier and thus leads to slow release. An emulsion method has been used to grow columnar crystals by mixing PNIPAM microgel dispersions with organic solvents. Effect of both temperature and microgel concentration on formation of columnar crystals has been studied. PNIPAM-co-NMA microgels have been used for the fabrication of crystalline hydrogel films by self-crosslinking microgels. The hydrogel film exhibits an iridescent. The thermally responsive properties and mechanical properties of this film have been studied. Melting temperature (Tm) of colloidal crystals self-assembled with PNIPAM-co-AAc microgels has been investigated as a function of pH, salt concentration and microgel concentration. It is revealed that Tm increases as pH value increases; Tm decreases with increase of salt concentration; Tm increases as microgel concentration increases. Phase behavior of PNIPAM-co-HEAc microgel dispersions has been investigated. It is observed that these microgel dispersions exhibit liquid, crystal, and glass phase. As microgel size increases, crystal phase shifts to low concentration range. As temperature increases, crystal phase shifts to high concentration ranges. These colloidal crystals can be stabilized by NaOH-induced gelation. Effect of NaOH concentration on formation of physical gelation has been investigated. |
author2 |
Hu, Zhibing |
author_facet |
Hu, Zhibing Zhou, Jun |
author |
Zhou, Jun |
author_sort |
Zhou, Jun |
title |
Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
title_short |
Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
title_full |
Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
title_fullStr |
Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
title_full_unstemmed |
Stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
title_sort |
stimuli-responsive microgels for self-assembled crystalline structures and controlled drug release. |
publisher |
University of North Texas |
publishDate |
2009 |
url |
https://digital.library.unt.edu/ark:/67531/metadc11001/ |
work_keys_str_mv |
AT zhoujun stimuliresponsivemicrogelsforselfassembledcrystallinestructuresandcontrolleddrugrelease |
_version_ |
1718429996547047424 |