Primary Cilia in the Oligodendrocyte Lineage
oligodendrocytes migrate from the corpus callosum into the overlying cortex. The incidence of cilia did not change markedly across age groups, and did not vary consistently with the number of processes per cell, which was used as an indication of the maturation stage of OPCs and young OLs. The mean...
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2013
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ndltd-unt.edu-info-ark-67531-metadc2718282019-04-20T06:09:07Z Primary Cilia in the Oligodendrocyte Lineage Hao, Yung-Chia Primary cilia oligodendrocyte precursor cell sonic hedgehog oligodendrocytes migrate from the corpus callosum into the overlying cortex. The incidence of cilia did not change markedly across age groups, and did not vary consistently with the number of processes per cell, which was used as an indication of the maturation stage of OPCs and young OLs. The mean percent of Olig1 immunopositive (Olig1+) cells having cilia across ages was 33.1% + 16.5%, with all ages combined. In O4+ cells of these mice, 56.7 + 3.6% had primary cilia. If it is the case that adult OLs do not have cilia, the point in the lineage when primary cilia are lost is still unknown. Adult mice that had been injected with cyclopamine to block cilia-dependent Shh signaling were examined to determine whether the rate of generating new OPCs was influenced. In the CC of control mice, the numerical density of Olig1+/BrdU+ cells was 1.29 + 0.07/mm2 was reduced to 0.68 + 0.38/mm2 in the cyclopamine-injected group, and the numerical density of all BrdU+ cells (including both Olig1+ and Olig1- cells) of 4.55 + 1.50/mm2 in the control group was reduced to 3.14 + 1.27/mm2 in the cyclopamine-injected group. However, there were only 2 mice in each group and the differences were not statistically significant. University of North Texas Fuchs, Jannon L. Root, Douglas D. Schwark, Harris D. 2013-05 Thesis or Dissertation Text https://digital.library.unt.edu/ark:/67531/metadc271828/ ark: ark:/67531/metadc271828 English Public Hao, Yung-Chia Copyright Copyright is held by the author, unless otherwise noted. All rights Reserved. |
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English |
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Primary cilia oligodendrocyte precursor cell sonic hedgehog |
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Primary cilia oligodendrocyte precursor cell sonic hedgehog Hao, Yung-Chia Primary Cilia in the Oligodendrocyte Lineage |
description |
oligodendrocytes migrate from the corpus callosum into the overlying cortex. The incidence of cilia did not change markedly across age groups, and did not vary consistently with the number of processes per cell, which was used as an indication of the maturation stage of OPCs and young OLs. The mean percent of Olig1 immunopositive (Olig1+) cells having cilia across ages was 33.1% + 16.5%, with all ages combined. In O4+ cells of these mice, 56.7 + 3.6% had primary cilia. If it is the case that adult OLs do not have cilia, the point in the lineage when primary cilia are lost is still unknown. Adult mice that had been injected with cyclopamine to block cilia-dependent Shh signaling were examined to determine whether the rate of generating new OPCs was influenced. In the CC of control mice, the numerical density of Olig1+/BrdU+ cells was 1.29 + 0.07/mm2 was reduced to 0.68 + 0.38/mm2 in the cyclopamine-injected group, and the numerical density of all BrdU+ cells (including both Olig1+ and Olig1- cells) of 4.55 + 1.50/mm2 in the control group was reduced to 3.14 + 1.27/mm2 in the cyclopamine-injected group. However, there were only 2 mice in each group and the differences were not statistically significant. |
author2 |
Fuchs, Jannon L. |
author_facet |
Fuchs, Jannon L. Hao, Yung-Chia |
author |
Hao, Yung-Chia |
author_sort |
Hao, Yung-Chia |
title |
Primary Cilia in the Oligodendrocyte Lineage |
title_short |
Primary Cilia in the Oligodendrocyte Lineage |
title_full |
Primary Cilia in the Oligodendrocyte Lineage |
title_fullStr |
Primary Cilia in the Oligodendrocyte Lineage |
title_full_unstemmed |
Primary Cilia in the Oligodendrocyte Lineage |
title_sort |
primary cilia in the oligodendrocyte lineage |
publisher |
University of North Texas |
publishDate |
2013 |
url |
https://digital.library.unt.edu/ark:/67531/metadc271828/ |
work_keys_str_mv |
AT haoyungchia primaryciliaintheoligodendrocytelineage |
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1719020230420725760 |