Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison
A rabbit keratoconjunctivities model was used to evaluate ophthalmic formulations containing 1 percent sodium cephalothin in silicon oil, a 1 percent sodium cephalothin aqueous solution, and a 0.3 percent gentamicin sulfate solution. Rabit eyes were inoculated intracorneally with Pseudomonas aerugi...
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North Texas State University
1979
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ndltd-unt.edu-info-ark-67531-metadc5040942017-03-17T08:41:25Z Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison Carney, Gerald R. eye diseases ophthalmology Ophthalmic drugs. Eye -- Microbiology. Sodium cephalothin. A rabbit keratoconjunctivities model was used to evaluate ophthalmic formulations containing 1 percent sodium cephalothin in silicon oil, a 1 percent sodium cephalothin aqueous solution, and a 0.3 percent gentamicin sulfate solution. Rabit eyes were inoculated intracorneally with Pseudomonas aeruginosa, Staphylococcus aureus, or Streptococcus pneumoniae, After topical treatment, none of the antibiotic formulations were effective in the P. aeruginosa model; all three showed good activity against S. aureus, and against S. pneumoniae, the caphalothin formulations were more effective than gentamicin.In a related stability study, the cephalothin potency of the silicon formulation was maintained for 16 weeks at 4, 25, and 450 C These studies suggest that sodium cephalothin can be formulated as an effective and stable ophthalmic dosage form. North Texas State University Vela, G. Roland, 1927- Jacobson, Myron 1979-08 Thesis or Dissertation v, 44 leaves : ill. Text local-cont-no: 1002772505-Carney untcat: b1177161 call-no: 379 N81 no. 5599 oclc: 5793199 https://digital.library.unt.edu/ark:/67531/metadc504094/ ark: ark:/67531/metadc504094 English Public Carney, Gerald R. Copyright Copyright is held by the author, unless otherwise noted. All rights reserved. |
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English |
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eye diseases ophthalmology Ophthalmic drugs. Eye -- Microbiology. Sodium cephalothin. |
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eye diseases ophthalmology Ophthalmic drugs. Eye -- Microbiology. Sodium cephalothin. Carney, Gerald R. Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison |
description |
A rabbit keratoconjunctivities model was used to evaluate ophthalmic formulations containing 1 percent sodium cephalothin in silicon oil, a 1 percent sodium cephalothin aqueous solution, and a 0.3 percent gentamicin sulfate solution. Rabit eyes were inoculated intracorneally with Pseudomonas aeruginosa, Staphylococcus aureus, or Streptococcus pneumoniae, After topical treatment, none of the antibiotic formulations were effective in the P. aeruginosa model; all three showed good activity against S. aureus, and against S. pneumoniae, the caphalothin formulations were more effective than gentamicin.In a related stability study, the cephalothin potency of the silicon formulation was maintained for 16 weeks at 4, 25, and 450 C These studies suggest that sodium cephalothin can be formulated as an effective and stable ophthalmic dosage form. |
author2 |
Vela, G. Roland, 1927- |
author_facet |
Vela, G. Roland, 1927- Carney, Gerald R. |
author |
Carney, Gerald R. |
author_sort |
Carney, Gerald R. |
title |
Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison |
title_short |
Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison |
title_full |
Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison |
title_fullStr |
Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison |
title_full_unstemmed |
Opthalmic Use Of Sodium Cephalothin: An In Vivo Comparison |
title_sort |
opthalmic use of sodium cephalothin: an in vivo comparison |
publisher |
North Texas State University |
publishDate |
1979 |
url |
https://digital.library.unt.edu/ark:/67531/metadc504094/ |
work_keys_str_mv |
AT carneygeraldr opthalmicuseofsodiumcephalothinaninvivocomparison |
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1718432474586939392 |