Immunocompetence in the AKR Mouse
A model for the study of the relationship of immunity to cancer is found in AKR mice which harbor Gross virus. This genetically transmitted virus is present in a latent form for months before it spontaneously induces leukemia. Many investigators have demonstrated near normal humoral responses, but a...
Main Author: | |
---|---|
Other Authors: | |
Format: | Others |
Language: | English |
Published: |
North Texas State University
1976
|
Subjects: | |
Online Access: | https://digital.library.unt.edu/ark:/67531/metadc504367/ |
id |
ndltd-unt.edu-info-ark-67531-metadc504367 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-unt.edu-info-ark-67531-metadc5043672017-03-17T08:41:25Z Immunocompetence in the AKR Mouse Dunton, Helen immune responses Immunocompetent cells. Oncogenic viruses. Cancer -- Immunological aspects. Mouse leukemia complex. Gross virus AKR mice A model for the study of the relationship of immunity to cancer is found in AKR mice which harbor Gross virus. This genetically transmitted virus is present in a latent form for months before it spontaneously induces leukemia. Many investigators have demonstrated near normal humoral responses, but abnormal cellular immunity in the preleukemic animal. With increasing age, pathology of the disease is expressed, reflecting diminished immunity. In this study, the ontogeny of humoral antibodies of AKR/J and SWR/J mice was assayed by microagglutination techniques in response to thymus-independent, thymus-dependent, and solubilized antigens. Simultaneous injections of thymusdependent and -independent antigens provided data suggesting an impaired humoral response in the AKR mouse. North Texas State University Hatten, Betty A. Johansson, Karl R. Kester, Andrew S. 1976-08 Thesis or Dissertation vi, 46 leaves: ill. Text local-cont-no: 1002773166-Dunton call-no: 379 N81 no.5206 untcat: b1136481 oclc: 2668716 https://digital.library.unt.edu/ark:/67531/metadc504367/ ark: ark:/67531/metadc504367 English Public Dunton, Helen Copyright Copyright is held by the author, unless otherwise noted. All rights reserved. |
collection |
NDLTD |
language |
English |
format |
Others
|
sources |
NDLTD |
topic |
immune responses Immunocompetent cells. Oncogenic viruses. Cancer -- Immunological aspects. Mouse leukemia complex. Gross virus AKR mice |
spellingShingle |
immune responses Immunocompetent cells. Oncogenic viruses. Cancer -- Immunological aspects. Mouse leukemia complex. Gross virus AKR mice Dunton, Helen Immunocompetence in the AKR Mouse |
description |
A model for the study of the relationship of immunity to cancer is found in AKR mice which harbor Gross virus. This genetically transmitted virus is present in a latent form for months before it spontaneously induces leukemia. Many investigators have demonstrated near normal humoral responses, but abnormal cellular immunity in the preleukemic animal. With increasing age, pathology of the disease is expressed, reflecting diminished immunity. In this study, the ontogeny of humoral antibodies of AKR/J and SWR/J mice was assayed by microagglutination techniques in response to thymus-independent, thymus-dependent, and solubilized antigens. Simultaneous injections of thymusdependent and -independent antigens provided data suggesting an impaired humoral response in the AKR mouse. |
author2 |
Hatten, Betty A. |
author_facet |
Hatten, Betty A. Dunton, Helen |
author |
Dunton, Helen |
author_sort |
Dunton, Helen |
title |
Immunocompetence in the AKR Mouse |
title_short |
Immunocompetence in the AKR Mouse |
title_full |
Immunocompetence in the AKR Mouse |
title_fullStr |
Immunocompetence in the AKR Mouse |
title_full_unstemmed |
Immunocompetence in the AKR Mouse |
title_sort |
immunocompetence in the akr mouse |
publisher |
North Texas State University |
publishDate |
1976 |
url |
https://digital.library.unt.edu/ark:/67531/metadc504367/ |
work_keys_str_mv |
AT duntonhelen immunocompetenceintheakrmouse |
_version_ |
1718432515079798784 |