Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure
In these studies, a procedure which allowed the in vivo labeling and detection of poly(ADP-ribose) was combined with nuclear fractionation techniques to analyze the nuclear distribution of ADP-ribose polymers. The results from these studies suggest the occurrence of poly(ADP-ribose) metabolism in tw...
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University of North Texas
1988
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ndltd-unt.edu-info-ark-67531-metadc7983802020-07-15T07:09:31Z Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure Cárdenas-Corona, María E. (María Elena) nucleoproteins chromatin ribose Nucleoproteins -- Metabolism. Chromatin. Ribose. In these studies, a procedure which allowed the in vivo labeling and detection of poly(ADP-ribose) was combined with nuclear fractionation techniques to analyze the nuclear distribution of ADP-ribose polymers. The results from these studies suggest the occurrence of poly(ADP-ribose) metabolism in two compartments of chromatin; one that is nuclear matrix-associated and one that is not. The biological significance of this compartmentalization is conceptualization in a model. This model postulates that, under some physiological conditions, poly(ADP-ribose) metabolism accomplishes the reversible targeting of specific regions of chromatin to the nuclear matrix domain by modulating DNA-protein and or protein-protein interactions. University of North Texas Jacobson, Myron Benjamin, Robert C. Pirtle, Robert M. Harris, Ben G. Wimbish, Gary Harold Wu, Edward 1988-08 Thesis or Dissertation xi, 163 leaves : ill. Text local-cont-no: 1002714868-Cardenas-Corona call-no: 379 N81d no.2865 untcat: b1690043 oclc: 28296566 https://digital.library.unt.edu/ark:/67531/metadc798380/ ark: ark:/67531/metadc798380 English Public Cárdenas-Corona, María E. (María Elena) Copyright Copyright is held by the author, unless otherwise noted. All rights |
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nucleoproteins chromatin ribose Nucleoproteins -- Metabolism. Chromatin. Ribose. |
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nucleoproteins chromatin ribose Nucleoproteins -- Metabolism. Chromatin. Ribose. Cárdenas-Corona, María E. (María Elena) Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure |
description |
In these studies, a procedure which allowed the in vivo labeling and detection of poly(ADP-ribose) was combined with nuclear fractionation techniques to analyze the nuclear distribution of ADP-ribose polymers. The results from these studies suggest the occurrence of poly(ADP-ribose) metabolism in two compartments of chromatin; one that is nuclear matrix-associated and one that is not. The biological significance of this compartmentalization is conceptualization in a model. This model postulates that, under some physiological conditions, poly(ADP-ribose) metabolism accomplishes the reversible targeting of specific regions of chromatin to the nuclear matrix domain by modulating DNA-protein and or protein-protein interactions. |
author2 |
Jacobson, Myron |
author_facet |
Jacobson, Myron Cárdenas-Corona, María E. (María Elena) |
author |
Cárdenas-Corona, María E. (María Elena) |
author_sort |
Cárdenas-Corona, María E. (María Elena) |
title |
Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure |
title_short |
Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure |
title_full |
Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure |
title_fullStr |
Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure |
title_full_unstemmed |
Studies on Poly(ADP-ribose) Metabolism and Chromatin Structure |
title_sort |
studies on poly(adp-ribose) metabolism and chromatin structure |
publisher |
University of North Texas |
publishDate |
1988 |
url |
https://digital.library.unt.edu/ark:/67531/metadc798380/ |
work_keys_str_mv |
AT cardenascoronamariaemariaelena studiesonpolyadpribosemetabolismandchromatinstructure |
_version_ |
1719329038832500736 |