Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection
Objective: The objective of this thesis was to compare demographic and clinical characteristics and factors associated with advanced hepatic fibrosis between HIV and HIV-hepatitis B (HBV) co-infected patients. Methods: Proportional odds models were developed to investigate socio-demographic and cli...
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Université d'Ottawa / University of Ottawa
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ndltd-uottawa.ca-oai-ruor.uottawa.ca-10393-381182018-09-16T09:09:34Z Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection Rana, Urvi Cooper, Curtis Lindsey Roy-Gagnon, Marie-Helene HIV HBV Co-infection CANOC Objective: The objective of this thesis was to compare demographic and clinical characteristics and factors associated with advanced hepatic fibrosis between HIV and HIV-hepatitis B (HBV) co-infected patients. Methods: Proportional odds models were developed to investigate socio-demographic and clinical variables’ association on liver fibrosis determined by AST-to-Platelet-Ratio-Index (APRI). Results: HBV status and APRI values were available for 2,419 of 9,289 (26%) participants. 199 (9%) were HBV co-infected. Compared to HIV infected, HIV-HBV co-infected individuals were 2.19 (95% CI: 1.63, 2.90) and 1.68 (95% CI: 1.10, 2.53) times more likely to belong in a higher level of APRI category. Compared to HIV mono-infection, HIV-HBV co-infected participants on ARV therapy were less likely to have clinically significant or advanced fibrosis compared to mild or moderate fibrosis. Conclusion: We provide evidence in favour of an association between ARV therapy and reduced fibrosis in HIV-HBV co-infected population. 2018-09-14T19:04:39Z 2018-09-14T19:04:39Z 2018-09-14 Thesis http://hdl.handle.net/10393/38118 http://dx.doi.org/10.20381/ruor-22373 en application/pdf Université d'Ottawa / University of Ottawa |
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HIV HBV Co-infection CANOC Rana, Urvi Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection |
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Objective: The objective of this thesis was to compare demographic and clinical characteristics and factors associated with advanced hepatic fibrosis between HIV and HIV-hepatitis B (HBV) co-infected patients.
Methods: Proportional odds models were developed to investigate socio-demographic and clinical variables’ association on liver fibrosis determined by AST-to-Platelet-Ratio-Index (APRI).
Results: HBV status and APRI values were available for 2,419 of 9,289 (26%) participants. 199 (9%) were HBV co-infected. Compared to HIV infected, HIV-HBV co-infected individuals were 2.19 (95% CI: 1.63, 2.90) and 1.68 (95% CI: 1.10, 2.53) times more likely to belong in a higher level of APRI category. Compared to HIV mono-infection, HIV-HBV co-infected participants on ARV therapy were less likely to have clinically significant or advanced fibrosis compared to mild or moderate fibrosis.
Conclusion: We provide evidence in favour of an association between ARV therapy and reduced fibrosis in HIV-HBV co-infected population. |
author2 |
Cooper, Curtis Lindsey |
author_facet |
Cooper, Curtis Lindsey Rana, Urvi |
author |
Rana, Urvi |
author_sort |
Rana, Urvi |
title |
Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection |
title_short |
Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection |
title_full |
Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection |
title_fullStr |
Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection |
title_full_unstemmed |
Characteristics and Clinical Outcomes in Antiretroviral Treated HIV-HBV Co-infection |
title_sort |
characteristics and clinical outcomes in antiretroviral treated hiv-hbv co-infection |
publisher |
Université d'Ottawa / University of Ottawa |
publishDate |
2018 |
url |
http://hdl.handle.net/10393/38118 http://dx.doi.org/10.20381/ruor-22373 |
work_keys_str_mv |
AT ranaurvi characteristicsandclinicaloutcomesinantiretroviraltreatedhivhbvcoinfection |
_version_ |
1718734497694875648 |