Enhancing Oncolytic Adenovirus Vector Efficacy through Co-expression of the p14 Fusion-associated Small Transmembrane Protein and Adenovirus Death Protein
Conditionally-replicating adenoviruses (CRAds) have generally demonstrated only modest therapeutic efficacy in human clinical trials, in part due to their poor ability to spread throughout a tumor mass. In these studies, I first examined whether inclusion of an intact early region 3 (E3) and t...
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| Format: | Others |
| Language: | en |
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Université d'Ottawa / University of Ottawa
2018
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| Online Access: | http://hdl.handle.net/10393/38379 http://dx.doi.org/10.20381/ruor-22632 |