Desenvolvimento da linhagem celular LEY79SF para produção de adenovírus livre de partículas competentes de replicação

Desenvolvimento da linhagem celular LEY79SF para produção de adenovírus livre de partículas competentes de replicação

A presença de Ad com competência para replicar (RCA, replication-competent adenovirus) nas preparações é um dos maiores problemas para a produção de Ad em larga escala. RCAs são gerados pela recombinação entre seqüência do vetor e seqüência homóloga do gene E1 presente nas células helper. Objetivo:...

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Bibliographic Details
Main Author:	Duarte, Patrícia
Other Authors:	Strauss, Eugenia Costanzi
Format:	Others
Language:	pt
Published:	Biblioteca Digitais de Teses e Dissertações da USP 2009
Subjects:	Adenovírus (produção) Adenovirus (production) Adenovírus competentesa de replicação Cell line Linhagem celular Linhagem celular Y79 Livre de RCA RCA - free Replication - competent adenovirus Retroviral vector Vetor retroviral Y79 cell line
Online Access:	http://www.teses.usp.br/teses/disponiveis/42/42134/tde-09022010-110303/

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