Application of 3D Hepatic Plate-Like Liver Model for Statin-Induced Hepatotoxicity Evaluation

Application of 3D Hepatic Plate-Like Liver Model for Statin-Induced Hepatotoxicity Evaluation

Background: Drug-induced liver injury is one of the main reasons of withdrawals of drugs in postmarketing stages. However, an experimental model(s) which can accurately recapitulates liver functions and reflects the level of drug hepatotoxicity is lack. In this study, we assessed drug hepatotoxicity...

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Bibliographic Details
Main Authors: Gao, Y. (Author), Han, X. (Author), Jia, Z. (Author), Li, S. (Author), Li, Y. (Author), Liang, K. (Author), Liao, W. (Author), Pan, D. (Author), Pan, M. (Author), Peng, Q. (Author), Weng, J. (Author), Xu, J. (Author), Zhou, S. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
3D culture
3-d cultures
Biomimetics
Co-culture system
Co-cultures
Diseases
Drug-induced liver injury
drug-induced liver injury (DILI)
hepatic plate
Hepatic plate
Hepatotoxicity
hydrogel
Hydrogel fibers
Hydrogels
Liver injuries
Plates (structural components)
polarity
Polarity
statins
Statins
Three dimensional computer graphics
Online Access:View Fulltext in Publisher

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