Porous Se@SiO2 Nanoparticles Enhance Wound Healing by ROS-PI3K/Akt Pathway in Dermal Fibroblasts and Reduce Scar Formation

Porous Se@SiO2 Nanoparticles Enhance Wound Healing by ROS-PI3K/Akt Pathway in Dermal Fibroblasts and Reduce Scar Formation

Hypertrophic scarring, which is characterized by excessive extracellular matrix deposition and abnormal fibroblast homeostasis, is an undesirable outcome of dermal wound healing. Once formed, the scar will replace the normal function of local skin, and there are few noninvasive clinical treatments t...

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Bibliographic Details
Main Authors: Cheng, T.-M (Author), Deng, G.-Y (Author), Li, X.-H (Author), Liu, S.-Y (Author), Liu, X.-J (Author), Shi, M.-J (Author), Song, J. (Author), Tian, Y. (Author), Yang, B.-Y (Author), Zhou, Z.-Y (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
Cell culture
Chemical activation
Dermal fibroblasts
Dermal wound healing
Extracellular matrix deposition
Fibroblasts
Fibrose
fibrosis
Homoeostasis
Normal function
oxidative stress
Oxidative stress
PI3K/akt pathway
PI3K/Akt pathways
Porous se@SiO2 nanoparticle
porous se@SiO2 nanoparticles
Scar formation
Silica nanoparticles
Silicon
SiO2 nanoparticles
Synthesis (chemical)
Tissue regeneration
wound healing
Wound healing
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