Transcriptome analysis in the spleen of Northern Snakehead (Channa argus) challenged with Nocardia seriolae

• Main Authors: Chen, H.J (Author), Ji, X.S (Author), Meng, Q.L (Author), Teng, J. (Author), Xue, L.Y (Author), Zhao, Y. (Author), Zhu, S.R (Author)
• Format: Article
• Language: English
• Published: Academic Press Inc. 2022
• Subjects: Immune response; Nocardia seriolae; Northern snakehead; Spleen; Transcriptome
• Online Access: View Fulltext in Publisher

 Northern snakehead (Channa argus) is an indigenous fish species and is one of popularly cultured snakeheads in China and other Asian countries. Unfortunately, Nocardia seriolae infections have caused considerable losses in the snakehead aquaculture industry. However, the infectivity and the immune response induced by N. seriolae in snakehead are unclear. In order to better understand the immune response of Northern snakehead in a series of time points after N. seriolae challenge, we conducted the transcriptomic comparison in snakehead spleen at 48, 96, and 144 h after the challenge of N. seriola against their control counterparts. Gene annotation and pathway analysis of differentially expressed genes (DEGs) were carried out to understand the functions of the DEGs. Additionally, protein-protein interaction networks were conducted to obtain the interaction relationships of immune-related DEGs. These results revealed the expression changes of multiple DEGs and signaling pathways involved in immunity during N. seriolae infection, which will facilitate our comprehensive understanding of the mechanisms involved in the immune response to bacterial infection in the northern snakehead. © 2022 The Authors