Spatial covariance analysis reveals the residue-by-residue thermodynamic contribution of variation to the CFTR fold
Although the impact of genome variation on the thermodynamic properties of function on the protein fold has been studied in vitro, it remains a challenge to assign these relationships across the entire polypeptide sequence in vivo. Using the Gaussian process regression based principle of Spatial CoV...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Research
2022
|
| Subjects: | |
| Online Access: | View Fulltext in Publisher |