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|a 14735709 (ISSN)
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|a The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium
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|b NLM (Medline)
|c 2022
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|a 10
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|z View Fulltext in Publisher
|u https://doi.org/10.1097/CEJ.0000000000000703
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|a BACKGROUND: Prior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity. OBJECTIVE: To investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis. METHODS: We included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs. RESULTS: We did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls. CONCLUSION: This study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk. Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
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|a case control study
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|a Case-Control Studies
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|a complication
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|a Diabetes Mellitus, Type 2
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|a Helicobacter infection
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|a Helicobacter Infections
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|a Helicobacter pylori
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|a Helicobacter pylori
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|a human
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|a Humans
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|a meta analysis
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|a non insulin dependent diabetes mellitus
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|a pathology
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|a risk factor
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|a Risk Factors
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|a Stomach Neoplasms
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|a stomach tumor
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|a Bertuccio, P.
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|a Boccia, S.
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|a Boffetta, P.
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|a Bonzi, R.
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|a Camargo, M.C.
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|a Dabo, B.
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|a Fernàndez de Larrea, N.
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|a Ferraroni, M.
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|a Gia Pham, A.
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|a Hamada, G.S.
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|a Hidaka, A.
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|a Jain, H.
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|a Kogevinas, M.
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|a Kurtz, R.C.
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|a La Vecchia, C.
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|a Lagiou, A.
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|a Lagiou, P.
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|a Lunet, N.
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|a Luu, H.N.
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|a Maximovitch, D.
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|a Muscat, J.
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|a Negri, E.
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|a Nguyen, T.C.
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|a Palli, D.
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|a Pastorino, R.
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|a Paula Curado, M.
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|a Pelucchi, C.
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|a Rota, M.
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|a Sanchez-Anguiano, A.
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|a Thi-Du Tran, C.
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|a Thi-Hai Pham, Y.
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|a Tsugane, S.
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|a Vioque, J.
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|a Yu, G.-P.
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|a Zaridze, D.
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|a Zhang, Z.-F.
|e author
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|t European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
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