Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy

Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy

MYC family oncoproteins are regulators of metabolic reprogramming that sustains cancer cell anabolism. Normal cells adapt to nutrient-limiting conditions by activating autophagy, which is required for amino acid (AA) homeostasis. Here we report that the autophagy pathway is suppressed by Myc in norm...

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Bibliographic Details
Main Authors: Ballabio, A. (Author), Berglund, A.E (Author), Chen, Z. (Author), Cleveland, J.L (Author), Dorsey, F.C (Author), Fernandez, M.R (Author), Koomen, J.M (Author), Li, W. (Author), Liu, M. (Author), Schaub, F.X (Author), Schaub, S.K (Author), Steeves, M.A (Author), Tzankov, A. (Author), Yang, C. (Author), Yun, S. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
amino acid
Amino Acids
animal
Animals
autophagy
Autophagy
basic helix loop helix leucine zipper transcription factor
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
genetics
homeostasis
Homeostasis
human
Humans
lysosome
Lysosomes
metabolism
Mice
mouse
physiology
proteasome
Proteasome Endopeptidase Complex
TFEB protein, human
Online Access:View Fulltext in Publisher

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