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02090nam a2200373Ia 4500 |
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10-1158-1078-0432-CCR-21-2750 |
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220420s2022 CNT 000 0 und d |
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|a 10780432 (ISSN)
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|a Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement
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|b American Association for Cancer Research Inc.
|c 2022
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|a 9
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|z View Fulltext in Publisher
|u https://doi.org/10.1158/1078-0432.CCR-21-2750
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|a Therapeutic advances for glioblastoma have been minimal over the past 2 decades. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase programs, a Society for Neuro-Oncology Think Tank was held in November 2020 to prioritize areas for improvement in the conduct of glioblastoma clinical trials. Here, we review the literature, identify challenges related to clinical trial eligibility criteria and trial design in glioblastoma, and provide recommendations from the Think Tank. In addition, we provide a data-driven context with which to frame this discussion by analyzing key study design features of adult glioblastoma clinical trials listed on ClinicalTrials.gov as “recruiting” or “not yet recruiting” as of February 2021. © 2021 American Association for Cancer Research
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|a Ahluwalia, M.S.
|e author
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|a Bagley, S.J.
|e author
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|a Chang, S.M.
|e author
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|a Cloughesy, T.F.
|e author
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|a Dunn, G.P.
|e author
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|a Galanis, E.
|e author
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|a Grossman, S.A.
|e author
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|a Khagi, S.
|e author
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|a Khasraw, M.
|e author
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|a Kothari, S.
|e author
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1 |
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|a Lee, E.Q.
|e author
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1 |
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|a Mehta, M.P.
|e author
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|a Nabors, L.B.
|e author
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1 |
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|a Rahman, R.
|e author
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|a Reardon, D.A.
|e author
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|a Sampson, J.H.
|e author
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|a Stupp, R.
|e author
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|a Sulman, E.P.
|e author
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|a Weller, M.
|e author
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|a Wen, P.Y.
|e author
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773 |
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|t Clinical Cancer Research
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