Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis
BACKGROUND: Although trials suggest that anti-inflammatory approaches targeting interleukin (IL)-6 signaling can reduce cardiovascular risk, it remains unknown whether targeting IL-6 signaling could reduce risk additively to low-density lipoprotein cholesterol (LDL-C) lowering. Here, we assess inter...
Main Authors: | Burgess, S. (Author), Dichgans, M. (Author), Georgakis, M.K (Author), Malik, R. (Author) |
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Format: | Article |
Language: | English |
Published: |
American Heart Association Inc.
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |
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