Clonal hematopoiesis in sickle cell disease
BACKGROUND. Curative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has prompted safety concerns. Individuals with SCD are predisposed to myeloid malignancies, but the underlying causes remain undefine...
Main Authors: | Abecasis, G.R (Author), Ashley-Koch, A. (Author), Bick, A.G (Author), Carneiro-Proietti, A.B (Author), Cato, L.D (Author), Custer, B. (Author), Dinardo, C.L (Author), Garrett, M.E (Author), Gladwin, M.T (Author), Kelly, S. (Author), Liggett, L.A (Author), Loureiro, P. (Author), Maximo, C. (Author), Natarajan, P. (Author), NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium (Author), Nouraie, S.M (Author), Reiner, A.P (Author), Sabino, E.C (Author), Sankaran, V.G (Author), Telen, M.J (Author), Weinstock, J.S (Author), Williams, D.A (Author), Zhang, Y. (Author) |
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Format: | Article |
Language: | English |
Published: |
American Society for Clinical Investigation
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |
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