| Summary: | Introduction: COVID-19 vaccines became available after being carefully monitored in clinical trials with safety and efficacy on the human body. However, a few recipients developed unusual side effects, including cerebral venous sinus thrombosis (CVST). We aim to systematically review the baseline features, clinical characteristics, treatment, and outcomes in patients developing CVST post-COVID-19 vaccination. Methods: This study was conducted according to the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) 2020 guideline. Investigators independently searched PubMed, Embase, and Google Scholar for English language articles published from inception up until September 10, 2021, reporting the incidence of CVST post-COVID-19 vaccines. We analyzed CVST patients’ baseline data, type of vaccines, clinical findings, treatment, and outcomes. Our systematic review process yielded patient-level data. Result: The final analysis included 25 studies that identified 80 patients who developed CVST after the COVID-19 vaccination. Of the 80 CVST cases, 31 (39.24%) patients died. There was no significant relationship between mortality and age (P =.733), sex (P =.095), vaccine type (P =.798), platelet count (P =.93), and comorbidities such as hypertension (P =.734) and diabetes mellitus (P =.758). However, mortality was associated with the duration of onset of CVST symptoms after vaccination (P =.022). Patients with CVST post-COVID-19 vaccination were more likely to survive if treated with an anticoagulant (P =.039). Patients who developed intracranial hemorrhage (P =.012) or thrombosis in the cortical vein (P =.021) were more likely to die. Conclusion: COVID-19 vaccine-associated CVST is associated with high mortality rate. Timely diagnosis and management can be lifesaving for patients. © The Author(s) 2022.
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