Reduced lung function predicts risk of incident type 2 diabetes: insights from a meta-analysis of prospective studies

Epidemiological studies have repeatedly investigated the association between reduced pulmonary function and incident type 2 diabetes mellitus (T2DM). However, the results have been inconsistent. This meta-analysis aimed to clarify this association with prospective cohort studies. We searched PubMed,...

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Bibliographic Details
Main Authors: Jiang, Y. (Author), Li, L. (Author), Meng, F. (Author), Wang, M. (Author), Yu, P. (Author), Zhou, Y. (Author)
Format: Article
Language:English
Published: Japan Endocrine Society 2022
Subjects:
Online Access:View Fulltext in Publisher
LEADER 02805nam a2200409Ia 4500
001 10-1507-endocrj-EJ21-0403
008 220425s2022 CNT 000 0 und d
020 |a 09188959 (ISSN) 
245 1 0 |a Reduced lung function predicts risk of incident type 2 diabetes: insights from a meta-analysis of prospective studies 
260 0 |b Japan Endocrine Society  |c 2022 
300 |a 7 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1507/endocrj.EJ21-0403 
520 3 |a Epidemiological studies have repeatedly investigated the association between reduced pulmonary function and incident type 2 diabetes mellitus (T2DM). However, the results have been inconsistent. This meta-analysis aimed to clarify this association with prospective cohort studies. We searched PubMed, Web of Science (ISI), and Google Scholar for all studies (in English) reporting reduced lung function with a risk of T2DM. The measures of lung function included percentage of forced vital capacity for predicted values (FVC%pre), percentage of forced expiratory volume in the first second after expiration for predicted values (FEV1%pre) and FEV1-to-FVC ratio%. Summary risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using fixed-effects or random-effects meta-analyses. A total of 5,480 incident T2DM patients among 88,799 individuals were identified from nine prospective cohort studies. Compared to the highest category of FVC%pre and FEV1%pre, the lowest category of FVC%pre and FEV1%pre were significantly associated with increased incident T2DM risk (FVC %pre: RR = 1.49, 95% CI: 1.39–1.59; FEV1%pre: RR = 1.52, 95% CI: 1.42–1.62). However, no significant relationship was found between the FEV1/FVC ratio and incident T2DM risk (RR = 1.01, 95% CI: 0.91–1.13). Current evidence suggests that restrictive rather than obstructive impairment of lung function is significantly associated with the incidence of T2DM. Further research is warranted to explore potential mediators of this relationship. © 2022 The Japan Endocrine Society. 
650 0 4 |a complication 
650 0 4 |a Diabetes Mellitus, Type 2 
650 0 4 |a forced expiratory volume 
650 0 4 |a Forced Expiratory Volume 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a lung 
650 0 4 |a Lung 
650 0 4 |a meta analysis 
650 0 4 |a non insulin dependent diabetes mellitus 
650 0 4 |a Prospective studies 
650 0 4 |a Prospective Studies 
650 0 4 |a prospective study 
650 0 4 |a Pulmonary function 
650 0 4 |a Type 2 diabetes 
650 0 4 |a vital capacity 
650 0 4 |a Vital Capacity 
700 1 |a Jiang, Y.  |e author 
700 1 |a Li, L.  |e author 
700 1 |a Meng, F.  |e author 
700 1 |a Wang, M.  |e author 
700 1 |a Yu, P.  |e author 
700 1 |a Zhou, Y.  |e author 
773 |t Endocrine Journal