Disentangling the Relationship Between Chronic Kidney Disease and Cognitive Disorders

• Main Authors: Kelly, D.M (Author), Rothwell, P.M (Author)
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2022
• Subjects: age; Alzheimer disease; amyloid beta protein; antihypertensive agent; anxiolytic agent; cerebrovascular accident; cerebrovascular disease; chronic kidney failure; CKD; cognitive defect; cognitive impairment; dementia; depression; diabetes mellitus; dialysis; disease association; disease predisposition; drug use; educational status; hemodialysis; hemodialysis patient; heredity; high risk population; human; hypertension; kidney transplantation; mild cognitive impairment; nervous system inflammation; obesity; pathogenesis; peritoneal dialysis; prevalence; Review; risk factor; sex difference; sleep disorder; stroke; uremia
• Online Access: View Fulltext in Publisher
• ISBN: 16642295 (ISSN)
• DOI: 10.3389/fneur.2022.830064

Chronic kidney disease (CKD) is a rapidly rising global health burden that affects nearly 40% of older adults. Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing cognitive disorders and dementia, and thus represent a vulnerable population. It is currently unknown to what extent this risk may be attributable to a clustering of traditional risk factors such as hypertension and diabetes mellitus leading to a high prevalence of both symptomatic and subclinical ischaemic cerebrovascular lesions, or whether other potential mechanisms, including direct neuronal injury by uraemic toxins or dialysis-specific factors could also be involved. These knowledge gaps may lead to suboptimal prevention and treatment strategies being implemented in this group. In this review, we explore the mechanisms of susceptibility and risk in the relationship between CKD and cognitive disorders. Copyright © 2022 Kelly and Rothwell.