PCSK9 Plasma Levels Are Associated with Mechanical Vascular Impairment in Familial Hypercholesterolemia Subjects without a History of Atherosclerotic Cardiovascular Disease: Results of Six-Month Add-On PCSK9 Inhibitor Therapy

PCSK9 Plasma Levels Are Associated with Mechanical Vascular Impairment in Familial Hypercholesterolemia Subjects without a History of Atherosclerotic Cardiovascular Disease: Results of Six-Month Add-On PCSK9 Inhibitor Therapy

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a key regulator of low-density lipoprotein (LDL) metabolism involved in the degradation of the low-density lipoprotein receptor (LDLR) through complex mechanisms. The PCSK9 plasma levels change according to lipid lowering therapy (LLT). Few da...

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Bibliographic Details
Main Authors: Cinquegrani, M. (Author), Di Pino, A. (Author), Ferrara, V. (Author), Gullo, A.L (Author), Imbalzano, E. (Author), Mandraffino, G. (Author), Morace, C. (Author), Piro, S. (Author), Purrello, F. (Author), Scicali, R. (Author), Scuruchi, M. (Author), Squadrito, G. (Author), Toscano, A. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
acetylsalicylic acid
adult
alirocumab
apolipoprotein B
arterial stiffness
Article
atherosclerosis
atherosclerotic injury
atorvastatin
biochemical analysis
body mass
breathing pattern
clopidogrel
cohort analysis
common carotid artery
controlled study
coronary artery atherosclerosis
diabetes mellitus
diastolic blood pressure
dyslipidemia
electrocardiogram
enzyme linked immunosorbent assay
evolocumab
ezetimibe
familial hypercholesterolemia
female
gene expression
genetic analysis
glucose blood level
heart infarction
hemoglobin A1c
heterozygosity
high density lipoprotein cholesterol
human
hypertension
hypertransaminasemia
low density lipoprotein cholesterol
low density lipoprotein receptor
major clinical study
male
mechanical vascular impairment
metformin
non insulin dependent diabetes mellitus
PCSK9
PCSK9 inhibitor
proprotein convertase 9
protein blood level
protein function
pulse wave velocity
risk factor
rosuvastatin
single nucleotide polymorphism
sulfonylurea
systolic blood pressure
triacylglycerol
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