TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells

TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells

Show other versions (1)

A Clostridioides difficile infection (CDI) is the most common nosocomial infection world-wide. The main virulence factors of pathogenic C. difficile are TcdA and TcdB, which inhibit small Rho-GTPases. The inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reor-ganization of...

Full description

Bibliographic Details
Main Authors:	Gerhard, R. (Author), Giehl, K. (Author), Hönig, R. (Author), Pich, A. (Author), Stieglitz, F. (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	C. diff Clostridioides difficile glucosyltransferase-independent effect phosphoproteomics pyknosis RAS TcdA TcdB
Online Access:	View Fulltext in Publisher

Similar Items

TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells
by: Gerhard, R., et al.
Published: (2022)

Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdB
by: Zhenghui Li, et al.
Published: (2020-06-01)

Loop mediated isothermal amplification of Clostridioides difficile isolates in gastrointestinal patients
by: Abbasi Montazeri, E., et al.
Published: (2022)

A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile
by: Bao-Zhong Zhang, et al.
Published: (2016-10-01)

High Serum Levels of Toxin A Correlate with Disease Severity in Patients with <i>Clostridioides difficile</i> Infection
by: Guido Granata, et al.
Published: (2021-09-01)

Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells
by: Johannes Junemann, et al.
Published: (2018-12-01)

Systematic Evaluation of Parameters Important for Production of Native Toxin A and Toxin B from <i>Clostridioides difficile</i>
by: Aria Aminzadeh, et al.
Published: (2021-03-01)

Prevalence, genotype and antimicrobial resistance of Clostridium difficile isolates from healthy pets in Eastern China
by: Yanxia Wei, et al.
Published: (2019-01-01)

Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile
by: Viola Fühner, et al.
Published: (2018-12-01)

The Enterotoxicity of Clostridium difficile Toxins
by: Hanping Feng, et al.
Published: (2010-07-01)

Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model
by: Yi-Wen Liu, et al.
Published: (2017-07-01)

The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins
by: Shuyi Chen, et al.
Published: (2015-12-01)

RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility
by: Adrianne N. Edwards, et al.
Published: (2019-03-01)

Comparative Whole Genome Sequence Analysis and Biological Features of Clostridioides difficile Sequence Type 2‡
by: Xingxing Xu, et al.
Published: (2021-07-01)

Gut Microbiota Composition Associated With Clostridium difficile-Positive Diarrhea and C. difficile Type in ICU Patients
by: Juping Duan, et al.
Published: (2020-05-01)

Receptor Binding Domains of TcdB from <i>Clostridioides difficile</i> for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
by: Daniel Henkel, et al.
Published: (2020-11-01)

The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
by: Florian Stieglitz, et al.
Published: (2021-09-01)

The role of the globular heads of the C1q receptor in TcdA-induced human colonic epithelial cell apoptosis via a mitochondria-dependent pathway
by: Jinhua Liang, et al.
Published: (2020-09-01)

A Two-Step Approach for Diagnosing Glutamate Dehydrogenase Genes by Conventional Polymerase Chain Reaction from Clostridium difficile Isolates
by: Sepideh Khodaparast, et al.
Published: (2019-07-01)

Clinical and microbiologic characteristics of <it>tcdA</it>-negative variant <it>clostridium difficile</it> infections
by: Kim Jieun, et al.
Published: (2012-05-01)

Putative Conjugative Plasmids with tcdB and cdtAB Genes in Clostridioides difficile
by: Gabriel Ramírez-Vargas, et al.
Published: (2020-09-01)

Occurrence of Clostridium difficile in two types of wastewater treatment plants
by: Mahnaz Nikaeen, et al.
Published: (2015-07-01)

Clostridioides difficile Infection
Published: (2022)

Fetal transcerebellar diameter to abdominal circumference ratio (TCD/AC) and to femur length ratio (TCD/FL) in the assessment of normal fetal growth
by: Karumanchi Ashok Hussain, et al.
Published: (2019-01-01)

Microevolution within ST11 group Clostridioides difficile isolates through mobile genetic elements based on complete genome sequencing
by: Yuan Wu, et al.
Published: (2019-10-01)

Estudo da imunopatogenia das lesões no sistema nervoso central de cães naturalmente acometidos por leishmaniose visceral
by: Tatianna Frate Schwardt, et al.
Published: (2012-12-01)

Online Environmental Control of Multiple Devices using Transcranial Doppler (TCD) Ultrasonography
by: Aleem, Idris Syed
Published: (2012)

Online Environmental Control of Multiple Devices using Transcranial Doppler (TCD) Ultrasonography
by: Aleem, Idris Syed
Published: (2012)

Integrating sporulation, toxin production and motility by redefining the role of TcdR and characterizing the sin region in Clostridium difficile
by: Parasumanna Girinathan, Brintha
Published: (2018)

Recurrent Clostridioides difficile infection: epidemiology and bedside scoring system analysis, 2014-2016
by: Orellana, Robert Charles
Published: (2018)

Bacteriophage endolysins as a potential weapon to combat Clostridioides difficile infection
by: Shakhinur Islam Mondal, et al.
Published: (2020-11-01)

Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection
by: Seung Woo Ahn, et al.
Published: (2021-09-01)

Factors and Conditions That Impact Electroporation of Clostridioides difficile Strains
by: Disha Bhattacharjee, et al.
Published: (2020-03-01)

Bacteriophages Contribute to Shaping Clostridioides (Clostridium) difficile Species
by: Louis-Charles Fortier
Published: (2018-08-01)

Risks and Preventive Strategies for Clostridioides difficile Transmission to Household or Community Contacts during Transition in Healthcare Settings
by: Ramin Asgary, et al.
Published: (2021-07-01)

The microbial diversity following antibiotic treatment of Clostridioides difficile infection
by: Dana Binyamin, et al.
Published: (2021-04-01)

Human and Porcine Transmission of Clostridioides difficile Ribotype 078, Europe
by: Geraldine Moloney, et al.
Published: (2021-09-01)

National Surveillance for Clostridioides difficile Infection, Sweden, 2009–2016
by: Kristina Rizzardi, et al.
Published: (2018-09-01)

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT
by: Michael Korbmacher, et al.
Published: (2020-08-01)

Investigational Treatment Agents for Recurrent Clostridioides difficile Infection (rCDI)
by: Kullar R, et al.
Published: (2020-10-01)