Target Design of Novel Histone Deacetylase 6 Selective Inhibitors with 2‐Mercaptoquinazolinone as the Cap Moiety

Epigenetic alterations found in all human cancers are promising targets for anticancer therapy. In this sense, histone deacetylase inhibitors (HDACIs) are interesting anticancer agents that play an important role in the epigenetic regulation of cancer cells. Here, we report 15 novel hydroxamic acid‐...

Full description

Bibliographic Details
Main Authors:	Bui, H.T.B (Author), Hong, Q.V (Author), Jung, H. (Author), Le, H.T (Author), Nguyen, P.H (Author), Nguyen, Q.C (Author), Nguyen, Q.P (Author), Pham, Q.M (Author), Tran, D.Q (Author), Tran, H.P (Author), Yang, S.-G (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	2‐mercaptoquinazolinone anticancer drugs antineoplastic agent Antineoplastic Agents antiproliferative activity cell proliferation Cell Proliferation chemical structure chemistry drug screening Drug Screening Assays, Antitumor Epigenesis, Genetic genetic epigenesis HDAC8 protein, human histone deacetylase histone deacetylase 6 Histone Deacetylase 6 histone deacetylase inhibitor Histone Deacetylase Inhibitors Histone Deacetylases human Humans hydroxamic acid‐based histone deacetylase inhibitors metabolism molecular docking Molecular Docking Simulation Molecular Structure repressor protein Repressor Proteins structure activity relation Structure-Activity Relationship tubulin acetylation level
Online Access:	View Fulltext in Publisher

by Bui, H.T.B, Hong, Q.V, Jung, H., Le, H.T, Nguyen, P.H, Nguyen, Q.C, Nguyen, Q.P, Pham, Q.M, Tran, D.Q, Tran, H.P, Yang, S.-G
Published 2022

View Fulltext in Publisher

Article

Target Design of Novel Histone Deacetylase 6 Selective Inhibitors with 2‐Mercaptoquinazolinone as the Cap Moiety

Similar Items