Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure–Activity Relationship

Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure–Activity Relationship

Show other versions (1)

The increase in the number of cases of type 2 diabetes mellitus (T2DM) and the complications associated with the side effects of chemical/synthetic drugs have raised concerns about the safety of the drugs. Hence, there is an urgent need to explore and identify natural bioactive compounds as alternat...

Full description

Bibliographic Details
Main Authors:	Alkhanani, M.F (Author), Chauhan, A. (Author), Dhama, K. (Author), Ghosh, A. (Author), Gurnani, M. (Author), Habeeballah, H. (Author), Haque, S. (Author), Jindal, T. (Author), Ranjan, A. (Author), Rath, P. (Author), Tuli, H.S (Author), Verma, N.K (Author)
Format:	Article
Language:	English
Published:	MDPI 2022
Subjects:	catalytic active site chemistry diabetes Diabetes Mellitus, Type 2 docking enzyme inhibitor Enzyme Inhibitors human Humans insulin resistance Insulin Resistance molecular docking Molecular Docking Simulation molecular dynamic simulation non insulin dependent diabetes mellitus polyphenol polyphenols Polyphenols protein tyrosine phosphatase 1B Protein Tyrosine Phosphatase, Non-Receptor Type 1 QSAR quantitative structure activity relation Quantitative Structure-Activity Relationship structure activity relation Structure-Activity Relationship
Online Access:	View Fulltext in Publisher

Similar Items

Potential Therapeutic Target Protein Tyrosine Phosphatase-1B for Modulation of Insulin Resistance with Polyphenols and Its Quantitative Structure–Activity Relationship
by: Alkhanani, M.F, et al.
Published: (2022)

Assessment of Antidiabetic Activity of the Shikonin by Allosteric Inhibition of Protein-Tyrosine Phosphatase 1B (PTP1B) Using State of Art: An In Silico and In Vitro Tactics
by: Mohd Saeed, et al.
Published: (2021-06-01)

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies
by: Jamshed Iqbal, et al.
Published: (2018-01-01)

Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
by: Farooq, R.K, et al.
Published: (2020)

Novel Mixed-Type Inhibitors of Protein Tyrosine Phosphatase 1B. Kinetic and Computational Studies
by: Marie Jazmín Sarabia-Sánchez, et al.
Published: (2017-12-01)

Deciphering the interactions of compounds from Allium sativum targeted towards identification of novel PTP 1B inhibitors in diabetes treatment: A computational approach
by: Oluwafemi Adeleke Ojo, et al.
Published: (2021-01-01)

Structure–Activity Relationship and Molecular Docking of a Kunitz-Like Trypsin Inhibitor, Kunitzin-AH, from the Skin Secretion of <i>Amolops hainanensis</i>
by: Yuqing Chen, et al.
Published: (2021-06-01)

QSAR, QSTR, and molecular docking studies of the anti-proliferative activity of phenylpiperazine derivatives against DU145 prostate cancer cell lines
by: Fabian A. Ikwu, et al.
Published: (2020-07-01)

Methodology for prediction of anticancer action of (2-oxo-2H-[1,2,4]¬triazino[2,3-c]-quinazolin-6-yl)thiones via QSAR and docking studies
by: I. S. Nosulenko, et al.
Published: (2015-02-01)

Environmentally Friendly Fluoroquinolone Derivatives with Lower Plasma Protein Binding Rate Designed Using 3D-QSAR, Molecular Docking and Molecular Dynamics Simulation
by: Yilin Hou, et al.
Published: (2020-09-01)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
by: Alshamrani, F.J, et al.
Published: (2019)

Study on Structure Activity Relationship of Natural Flavonoids against Thrombin by Molecular Docking Virtual Screening Combined with Activity Evaluation In Vitro
by: Xiaoyan Wang, et al.
Published: (2020-01-01)

In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B
by: Rosaria Ottanà, et al.
Published: (2021-01-01)

QSAR analysis and molecular docking study of pyrrolo- and pyridoquinolinecarboxamides with diuretic activity
by: Mykola Golik, et al.
Published: (2021-06-01)

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases
by: Yan Guo, et al.
Published: (2020-01-01)

Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis
by: Von Novi O. de Leon, et al.
Published: (2021-07-01)

Synthesis and α-glucosidase inhibition activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo[e][1,2]thiazin-2-yl]-n-arylacetamides: An in silico and biochemical approach
by: Ahmad, M., et al.
Published: (2021)

QSAR study and molecular docking of benzimidazole derivatives as potent activators of AMP-activated protein kinase
by: Nidal Naceiri Mrabti, et al.
Published: (2017-01-01)

Looking at Marine-Derived Bioactive Molecules as Upcoming Anti-Diabetic Agents: A Special Emphasis on PTP1B Inhibitors
by: Shahira M. Ezzat, et al.
Published: (2018-12-01)

Synthesis of Bi-heterocyclic sulfonamides as tyrosinase inhibitors: Lineweaver-burk plot evaluation and computational ascriptions
by: Abbasi, M.M, et al.
Published: (2020)

<i>Leishmania mexicana</i> Trypanothione Reductase Inhibitors: Computational and Biological Studies
by: Félix Matadamas-Martínez, et al.
Published: (2019-09-01)

Design, Synthesis, and Bioactive Screen In Vitro of Cyclohexyl (<i>E</i>)-4-(Hydroxyimino)-4-Phenylbutanoates and Their Ethers for Anti-Hepatitis B Virus Agents
by: Xinhua Cui, et al.
Published: (2019-05-01)

New 3-O-substituted xanthone derivatives as promising acetylcholinesterase inhibitors
by: Zi Han Loh, et al.
Published: (2021-01-01)

Rational in silico drug design of HIV-RT inhibitors through G-QSAR and molecular docking study of 4-arylthio and 4-aryloxy-3-iodopyridine-2(1-H)-one derivative
by: Debadash Panigrahi, et al.
Published: (2020-11-01)

Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study
by: Pradeep Paudel, et al.
Published: (2018-05-01)

Cinnamide Derivatives as Mammalian Arginase Inhibitors: Synthesis, Biological Evaluation and Molecular Docking
by: Thanh-Nhat Pham, et al.
Published: (2016-09-01)

Polyphenols from Erythrina crista-galli: Structures, Molecular Docking and Phytoestrogenic Activity
by: Naglaa S. Ashmawy, et al.
Published: (2016-06-01)

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy
by: Lingling Yang, et al.
Published: (2020-01-01)

Bitter melon triterpenes work as insulin sensitizers and insulin substitutes in insulin-resistant cells
by: Chi-I Chang, et al.
Published: (2015-03-01)

Quantitative Structure Activity Relationship Studies and Molecular Dynamics Simulations of 2-(Aryloxyacetyl)cyclohexane-1,3-Diones Derivatives as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors
by: Ying Fu, et al.
Published: (2019-08-01)

Design and Synthesis of New Benzophenone Derivatives with In Vivo Anti-Inflammatory Activity through Dual Inhibition of Edema and Neutrophil Recruitment
by: Jaqueline P. Januario, et al.
Published: (2018-07-01)

Flexibility in the Insulin Receptor Ectodomain Enables Docking of Insulin in Crystallographic Conformation Observed in a Hormone-Bound Microreceptor
by: Harish Vashisth
Published: (2014-10-01)

Multi-Target Actions of Acridones from <i>Atalantia monophylla</i> towards Alzheimer’s Pathogenesis and Their Pharmacokinetic Properties
by: Pitchayakarn Takomthong, et al.
Published: (2021-08-01)

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease
by: Jun Mo, et al.
Published: (2020-01-01)

Evaluation of Firefly and <i>Renilla</i> Luciferase Inhibition in Reporter-Gene Assays: A Case of Isoflavonoids
by: Maša Kenda, et al.
Published: (2021-06-01)

In silico studies of piperazine derivatives as potent anti-proliferative agents against PC-3 prostate cancer cell lines
by: Fabian A. Ikwu, et al.
Published: (2020-01-01)

cis-2 and trans-2-eicosenoic Fatty Acids Inhibit Mycobacterium tuberculosis Virulence Factor Protein Tyrosine Phosphatase B
by: Lalu Rudyat Telly SAVALAS, et al.
Published: (2021-08-01)

Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: In vitro evaluation and docking study
by: Abuelizz, H.A, et al.
Published: (2019)

In silico design and molecular docking study of CDK2 inhibitors with potent cytotoxic activity against HCT116 colorectal cancer cell line
by: Fabian Adakole Ikwu, et al.
Published: (2020-09-01)

Discovery of amide-functionalized benzimidazolium salts as potent α-glucosidase inhibitors
by: Ahmad, M., et al.
Published: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4s1ubv27ug2oi39v60hksa1qu0