Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...

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Bibliographic Details
Main Authors: Andrade, J.G (Author), Andreani, M. (Author), Balasubramanian, S. (Author), Chait, B.T (Author), Di Virgilio, M. (Author), Donaldson, A.D (Author), Garzón, J. (Author), Hiraga, S.-I (Author), Mertins, P. (Author), Popp, O. (Author), Rahjouei, A. (Author), Rosen, D.B (Author), Saha, T. (Author), Sundaravinayagam, D. (Author), Zhang, W. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
cancer biology
DNA replication fork protection
DSB resection inhibition
genetics
genomics
intrinsically disordered region
mouse
RIF1
SQ motifs
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