Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
RIF1 is a multifunctional protein that plays key roles in the regulation of DNA processing. During repair of DNA double-strand breaks (DSBs), RIF1 functions in the 53BP1-Shieldin pathway that inhibits resection of DNA ends to modulate the cellular decision on which repair pathway to engage. Under co...
Main Authors: | Andrade, J.G (Author), Andreani, M. (Author), Balasubramanian, S. (Author), Chait, B.T (Author), Di Virgilio, M. (Author), Donaldson, A.D (Author), Garzón, J. (Author), Hiraga, S.-I (Author), Mertins, P. (Author), Popp, O. (Author), Rahjouei, A. (Author), Rosen, D.B (Author), Saha, T. (Author), Sundaravinayagam, D. (Author), Zhang, W. (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
NLM (Medline)
2022
|
Subjects: | |
Online Access: | View Fulltext in Publisher |
Similar Items
-
Forks on the Run: Can the Stalling of DNA Replication Promote Epigenetic Changes?
by: Hollie Rowlands, et al.
Published: (2017-06-01) -
Rif1 Regulates the Fate of DNA Entanglements during Mitosis
by: Sophie Zaaijer, et al.
Published: (2016-06-01) -
Homologous Recombination as a Replication Fork Escort: Fork-Protection and Recovery
by: Audrey Costes, et al.
Published: (2012-12-01) -
53BP1 and BRCA1 control pathway choice for stalled replication restart
by: Yixi Xu, et al.
Published: (2017-11-01) -
Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action
by: Shin-Ya Isobe, et al.
Published: (2021-07-01)