Image-based computational fluid dynamics for estimating pressure drop and fractional flow reserve across iliac artery stenosis: A comparison with in-vivo measurements

• Main Authors: Hall Barrientos, P. (Author), Mark, P. (Author), Matthews, J. (Author), Paul, M.C (Author), Radjenovic, A. (Author), Roditi, G. (Author), Skopalik, S. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: Boundary conditions; CFD; Computational fluid dynamics; Condition parameters; Constriction, Pathologic; coronary angiography; Coronary Angiography; Coronary arteries; coronary artery obstruction; coronary blood vessel; Coronary Stenosis; Coronary Vessels; diagnostic imaging; Diameter reduction; Different boundary condition; Drops; FFR; fractional flow reserve; Fractional Flow Reserve, Myocardial; Fractional flow reserves; human; Humans; hydrodynamics; Hydrodynamics; iliac artery; Iliac Artery; iliac artery stenosis; In-vivo measurement; Magnetic resonance imaging; Noninvasive medical procedures; Noninvasive methods; Phase contrast magnetic resonance imaging; pressure drop; Pressure drop; procedures; stenosis, occlusion and obstruction
• Online Access: View Fulltext in Publisher

 Computational Fluid Dynamics (CFD) and time-resolved phase-contrast magnetic resonance imaging (PC-MRI) are potential non-invasive methods for the assessment of the severity of arterial stenoses. Fractional flow reserve (FFR) is the current “gold standard” for determining stenosis severity in the coronary arteries but is an invasive method requiring insertion of a pressure wire. CFD derived FFR (vFFR) is an alternative to traditional catheter derived FFR now available commercially for coronary artery assessment, however, it can potentially be applied to a wider range of vulnerable vessels such as the iliac arteries. In this study CFD simulations are used to assess the ability of vFFR in predicting the stenosis severity in a patient with a stenosis of 77% area reduction (>50% diameter reduction) in the right iliac artery. Variations of vFFR, overall pressure drop and flow split between the vessels were observed by using different boundary conditions. Correlations between boundary condition parameters and resulting flow variables are presented. The study concludes that vFFR has good potential to characterise iliac artery stenotic disease. © 2021 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.