Congenital Deafness and Recent Advances Towards Restoring Hearing Loss

• Main Authors: Basch, M.L (Author), Renauld, J.M (Author)
• Format: Article
• Language: English
• Published: Blackwell Publishing Inc. 2021
• Subjects: agents acting on the auditory and vestibular systems; alcohol; alcohol consumption; animal; animal models; Animals; Article; bf 844; brain stem response; branchiootorenal syndrome; chick; cochlea potential; cochlear implantation; Cochlear Implantation; congenital deafness; connexin 26; Cytomegalovirus; Deafness; distortion product otoacoustic emission; gene editing; gene therapy; genetics; hearing aid; Hearing Aids; hearing impairment; hearing loss; Hearing Loss; Hearing Loss, Sensorineural; herpes simplex; human; jaundice; Jervell and Lange-Nielsen syndrome; Lymphocytic choriomeningitis virus; mouse model; nonhuman; opiate; otoferlin; pathophysiology; Pendred syndrome; pendrin; perception deafness; priority journal; protein; protein function; rodent model; rubella; startle reflex; syndromic deafness; Toxoplasma gondii; toxoplasmosis; Treponema pallidum; unclassified drug; Usher syndrome; virus infection; Waardenburg syndrome; zebra fish; Zika virus
• Online Access: View Fulltext in Publisher
• ISBN: 26911299 (ISSN)
• DOI: 10.1002/cpz1.76

Congenital hearing loss is the most common birth defect, estimated to affect 2-3 in every 1000 births. Currently there is no cure for hearing loss. Treatment options are limited to hearing aids for mild and moderate cases, and cochlear implants for severe and profound hearing loss. Here we provide a literature overview of the environmental and genetic causes of congenital hearing loss, common animal models and methods used for hearing research, as well as recent advances towards developing therapies to treat congenital deafness. © 2021 The Authors. © 2021 The Authors.