Proactive inhibition is not modified by deep brain stimulation for Parkinson's disease: An electrical neuroimaging study

• Main Authors: Accolla, E.A (Author), De Pretto, M. (Author), Debove, I. (Author), Mouthon, M. (Author), Pollo, C. (Author), Schüpbach, M. (Author), Spierer, L. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; aged; Aged; Article; brain depth stimulation; brain function; clinical article; cohort analysis; controlled study; data analysis software; Deep Brain Stimulation; diagnostic imaging; EEG; electroencephalogram; electroencephalography; Electroencephalography; female; Female; frontal cortex; frontobasal network; globus pallidus; Globus Pallidus; Go No Go task; human; Humans; indirect pathway; inhibitory control; internal globus pallidus; male; Male; middle aged; Middle Aged; motor performance; nerve cell network; Nerve Net; neuroimaging; occipital cortex; outcome assessment; parietal cortex; Parkinson disease; Parkinson Disease; pathophysiology; physiology; premotor cortex; proactive inhibition; Proactive Inhibition; procedures; psychomotor performance; Psychomotor Performance; reaction time; subthalamic nucleus; Subthalamic Nucleus; task performance
• Online Access: View Fulltext in Publisher

 In predictable contexts, motor inhibitory control can be deployed before the actual need for response suppression. The brain functional underpinnings of proactive inhibition, and notably the role of basal ganglia, are not entirely identified. We investigated the effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in patients with Parkinson's disease. They completed a cued go/no-go proactive inhibition task ON and (unilateral) OFF stimulation while EEG was recorded. We found no behavioural effect of either subthalamic nucleus or internal globus pallidus deep brain stimulation on proactive inhibition, despite a general improvement of motor performance with subthalamic nucleus stimulation. In the non-operated and subthalamic nucleus group, we identified periods of topographic EEG modulation by the level of proactive inhibition. In the subthalamic nucleus group, source estimation analysis suggested the initial involvement of bilateral frontal and occipital areas, followed by a right lateralized fronto-basal network, and finally of right premotor and left parietal regions. Our results confirm the overall preservation of proactive inhibition capacities in both subthalamic nucleus and internal globus pallidus deep brain stimulation, and suggest a partly segregated network for proactive inhibition, with a preferential recruitment of the indirect pathway. © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.