Cannabis use impacts pre-stimulus neural activity in the visual cortices of people with HIV

• Main Authors: Christopher-Hayes, N.J (Author), Lew, B.J (Author), May, P.E (Author), O'Neill, J. (Author), Schantell, M. (Author), Swindells, S. (Author), Wiesman, A.I (Author), Wilson, T.W (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; Adult; Article; brain function; brain region; Brain Waves; cannabinoid receptor affecting agent; Cannabinoid Receptor Modulators; cannabis; cannabis addiction; cannabis use; CD4 antigen; cognition; cognitive defect; Cognitive Dysfunction; complication; controlled study; depth perception; drug effect; electroencephalogram; false positive result; female; Female; gamma; HIV Infections; human; Human immunodeficiency virus; Human immunodeficiency virus infection; Humans; magnetoencephalography; Magnetoencephalography; major clinical study; male; Male; medical cannabis; Medical Marijuana; MEG; middle aged; Middle Aged; molecular dynamics; nerve cell; nerve potential; neural oscillations; neurocognitive decline; neuropsychological test; nuclear magnetic resonance imaging; oscillation; parietal cortex; pathophysiology; physiology; stimulus response; task performance; time series analysis; vision; visual cortex; Visual Cortex; Visual Perception; visuospatial processing; visuospatial processing task
• Online Access: View Fulltext in Publisher

 People with HIV (PWH) use cannabis at a higher rate than the general population, but the influence on neural activity is not well characterized. Cannabis use among PWH may have a beneficial effect, as neuroinflammation is known to be a critical problem in PWH and cannabis use has been associated with a reduction in proinflammatory markers. Thus, it is important to understand the net impact of cannabis use on brain and cognitive function in PWH. In this study, we collected magnetoencephalographic (MEG) brain imaging data on 81 participants split across four demographically matched groups (i.e., PWH using cannabis, controls using cannabis, non-using PWH, and non-using controls). Participants completed a visuospatial processing task during MEG. Time–frequency resolved voxel time series were extracted to identify the dynamics of oscillatory and pre-stimulus baseline neural activity. Our results indicated strong theta (4–8 Hz), alpha (10–16 Hz), and gamma (62–72 Hz) visual oscillations in parietal–occipital brain regions across all participants. PWH exhibited significant behavioral deficits in visuospatial processing, as well as reduced theta oscillations and elevated pre-stimulus gamma activity in visual cortices, all of which replicate prior work. Strikingly, chronic cannabis use was associated with a significant reduction in pre-stimulus gamma activity in the visual cortices, such that PWH no longer statistically differed from controls. These results provide initial evidence that cannabis use may normalize some neural aberrations in PWH. This study fills an important gap in understanding the impact of cannabis use on brain and cognitive function in PWH. © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.