Identification and external validation of the optimal FIB-4 and APRI thresholds for ruling in chronic hepatitis B related liver fibrosis in tertiary care settings

Identification and external validation of the optimal FIB-4 and APRI thresholds for ruling in chronic hepatitis B related liver fibrosis in tertiary care settings

Background: With the initially defined thresholds, the most widely used serum biomarkers for staging liver fibrosis (ie, APRI and FIB-4 scores) proved to be ineffective among patients with chronic hepatitis B virus infection (CHB). Whether optimizing the FIB-4 and APRI thresholds could improve their...

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Bibliographic Details
Main Authors: Cai, F. (Author), Huang, J. (Author), Liang, Z. (Author), Liu, K. (Author), Liu, S. (Author), Peng, P. (Author), Qin, M. (Author), Tao, K. (Author), Zhao, L. (Author), Zou, J. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
adult
Adult
alanine aminotransferase
Alanine Transaminase
aminotransferase
Article
aspartate aminotransferase to platelet ratio index
biomarkers
blood
chronic hepatitis B
clinical decision rules
cohort analysis
complication
controlled study
diagnostic accuracy
diagnostic error
diagnostic errors
diagnostic test accuracy study
external validity
female
Female
Fibrosis-4 Index
hepatitis B
Hepatitis B, Chronic
human
Humans
internal validity
liver cirrhosis
Liver Cirrhosis
liver fibrosis
major clinical study
male
Male
middle aged
Middle Aged
pathology
platelet count
Platelet Count
predictive value
receiver operating characteristic
reproducibility
Reproducibility of Results
sensitivity and specificity
staging
tertiary care center
tertiary health care
Tertiary Healthcare
Transaminases
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