Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression

Transcription factor FOXA3 promotes the development of Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression

Objective: In this research paper, we aimed to study the role of FOXA3 in hepatoblastoma (HB) and the molecular mechanism. Methods: Immunohistochemistry was applied to determine the expression situation of FOXA3 and AFP in HB tissues and the adjacent normal tissues. FOXA3, HNF1A, and ZFHX3 expressio...

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Bibliographic Details
Main Authors: Zhan, X. (Author), Zhao, A. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
AFP
AFP protein, human
alpha fetoprotein
alpha-Fetoproteins
Article
cancer tissue
cell assay
cell cloning
cell protein
cell survival
Cell Survival
cell viability
child
Child, Preschool
clinical article
colony formation
controlled study
down regulation
female
Female
FOXA3
FOXA3 protein, human
gene control
gene expression
gene knockdown
genetics
hepatoblastoma
Hepatoblastoma
hepatoblastoma cell line
hepatocyte nuclear factor 1alpha
Hepatocyte Nuclear Factor 1-alpha
hepatocyte nuclear factor 3gamma
Hepatocyte Nuclear Factor 3-gamma
HNF1A
HNF1A protein, human
homeodomain protein
Homeodomain Proteins
human
human cell
human tissue
Humans
immunohistochemistry
infant
Infant
Liver Neoplasms
liver tumor
male
Male
metabolism
Myc protein
pathology
preschool child
protein expression
transcription
unclassified drug
upregulation
Western blotting
ZFHX3 protein
ZFHX3 protein, human
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