Alcohol consumption and serum uric acid are synergistically associated with renal dysfunction among community-dwelling persons

• Main Authors: Akase, T. (Author), Kawamoto, R. (Author), Kikuchi, A. (Author), Kumagi, T. (Author), Ninomiya, D. (Author), Tokumoto, Y. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adverse event; aged; Aged; alcohol consumption; Alcohol Drinking; Article; blood; chronic kidney failure; community dwelling person; complication; confounding variable; controlled study; Cross-Sectional Studies; cross-sectional study; drinking behavior; eGFR; estimated glomerular filtration rate; female; Female; follow up; Follow-Up Studies; Glomerular Filtration Rate; glomerulus filtration rate; human; Humans; hyperuricemia; Hyperuricemia; independent living; Independent Living; interactive effects; kidney failure; kidney function; major clinical study; male; Male; pathology; patient participation; prognosis; Prognosis; Renal Insufficiency, Chronic; risk factor; Risk Factors; rural area; serum uric acid; sex difference; sex factor; Sex Factors; uric acid; Uric Acid; uric acid blood level
• Online Access: View Fulltext in Publisher

 Background: Serum uric acid (SUA) is a key risk factor contributing to renal failure, a serious public health problem. However, few studies have examined whether the interactive relationship between alcohol consumption and SUA is independently associated with the estimated glomerular filtration rate (eGFR). Methods: Our sample comprised 742 men aged 69 ± 11 years (mean ± standard deviation) and 977 women aged 69 ± 10 years from a rural area. We cross-sectionally examined the relationships between the confounding factors of alcohol consumption and SUA with renal function denoted by eGFR estimated using CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations modified by a Japanese coefficient. Results: In both genders, eGFR increased with a rise in alcohol consumption. This tendency was more pronounced in participants with hyperuricemia, where SUA was greater than 7.0 mg/dL in men and greater than 6.0 mg/dl in women (men: F = 41.98, p < 0.001; women: F = 41.98, p < 0.001). A multiple linear regression analysis showed that alcohol consumption (men: β = 0.112, p < 0.001; women: β = 0.060, p = 0.011) and SUA (men: β = −0.282, p < 0.001; women: β = 0.317, p < 0.001) were significantly and independently related to eGFR. Further, the interactive relationship between alcohol consumption and SUA (men: F = 6.388, p < 0.001; women: F = 5.368, p < 0.001) was a significant and independent indicator of eGFR. Conclusions: These results suggested that alcohol consumption and SUA were synergistically associated with renal dysfunction among community-dwelling persons. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC