Serum osteoprotegerin level in hemodialysis patients using low-flux reused dialyzer in relation to atherosclerosis

• Main Authors: Bui Thi Thu, H. (Author), Can Van, M. (Author), Dao Bui Quy, Q. (Author), Do Van, T. (Author), Do, Q. (Author), Le Thi Huong, L. (Author), Le Viet, T. (Author), Nguyen Cong, H. (Author), Nguyen Duy, T. (Author), Nguyen Minh, T. (Author), Nguyen Trung, K. (Author), Pham Quoc, T. (Author), Tran Viet, T. (Author)
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2021
• Subjects: adult; Adult; Article; atherosclerosis; Atherosclerosis; blood; carotid artery disease; Carotid Artery Diseases; carotid atherosclerosis; clinical trial; controlled study; devices; diagnostic test accuracy study; female; Female; hemodialysis; human; Humans; Logistic Models; major clinical study; male; Male; middle aged; Middle Aged; multicenter study; osteoprotegerin; Osteoprotegerin; predictive value; procedures; prognosis; protein blood level; receiver operating characteristic; Renal Dialysis; risk factor; sensitivity and specificity; serum osteoprotegerin; statistical model; TNFRSF11B protein, human
• Online Access: View Fulltext in Publisher

 Aims: To assess the relation of high serum OPG level and carotid atherosclerosis in maintenance hemodialysis (MHD) patients using low-flux reused dialyzer. Materials and Methods: We examined 209 MHD patients with and without carotid atherosclerosis (83 patients and 126 patients) to establish the relation between OPG and atherosclerosis. Results: The proportion of carotid atherosclerosis was 39.7%. The median serum OPG level was 45.3 pmol/L. Serum OPG had a good predicting value for atherosclerosis in MHD patients using low-flux reused dialyzer (AUC = 0.934, p < 0.001, cutoff value = 43.35 pmol/L, Se = 81.3%, Sp = 90.9%). Conclusions: In this study, serum OPG had a good predicting value for atherosclerosis in MHD patients using low-flux reused dialyzer. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.