CircRNAs as promising biomarker in diagnosis of breast cancer: An updated meta-analysis

Background: Circular RNAs (circRNAs) have been identified to be involved in onset and progression of multiple malignant tumors. The present study aimed to systematically evaluate the diagnostic values of circRNAs in breast cancer. Methods: The PubMed, Web of Science, Embase, CNKI, and Wanfang online...

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Bibliographic Details
Main Authors: Chu, M. (Author), Fang, Y. (Author), Jin, Y. (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2021
Subjects:
Online Access:View Fulltext in Publisher
LEADER 03384nam a2200529Ia 4500
001 10.1002-jcla.23934
008 220427s2021 CNT 000 0 und d
020 |a 08878013 (ISSN) 
245 1 0 |a CircRNAs as promising biomarker in diagnosis of breast cancer: An updated meta-analysis 
260 0 |b John Wiley and Sons Inc  |c 2021 
856 |z View Fulltext in Publisher  |u https://doi.org/10.1002/jcla.23934 
520 3 |a Background: Circular RNAs (circRNAs) have been identified to be involved in onset and progression of multiple malignant tumors. The present study aimed to systematically evaluate the diagnostic values of circRNAs in breast cancer. Methods: The PubMed, Web of Science, Embase, CNKI, and Wanfang online databases were searched for the relevant studies before December 31, 2020. Statistical analysis of the diagnostic tests was performed based on STATA 16.0, Meta-DiSc 1.4, and RevMan 5.3 software. The threshold effect and publication bias were measured by the Spearman correlation and Deeks’ funnel plot asymmetry test, respectively. Results: Twenty-one studies from 13 articles were included in this meta-analysis. The pooled sensitivity and specificity were 0.77 and 0.71, respectively. The pooled positive likelihood ratio (PLR), negative likelihood ratio (NLR), and overall diagnostic odds ratio (DOR) were 2.6, 0.33, and 8, respectively. Furthermore, the area under the summary receiver operator characteristic curve was 0.80. In addition, down-regulated circRNAs achieved a diagnostic performance higher than up-regulated circRNAs, with area under curve (AUC) values of 0.81 and 0.74, respectively. Studies based on tissue samples presented better diagnostic accuracy than those based on plasma samples, with AUC values of 0.80 and 0.67. In addition, two circRNAs, including circ_0001073 and circTADA2A-E5/E6, showed higher diagnostic values, with AUC value of 0.990 and 0.937, respectively. According to the results of meta-regression, the case size (p<0.05) might be the source of the heterogeneity. Conclusion: CircRNAs exhibited a high diagnostic value for breast cancer and may function as potential diagnostic biomarkers for breast cancer. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. 
650 0 4 |a area under the curve 
650 0 4 |a Article 
650 0 4 |a biomarker 
650 0 4 |a Biomarkers, Tumor 
650 0 4 |a blood 
650 0 4 |a breast cancer 
650 0 4 |a breast cancer 
650 0 4 |a Breast Neoplasms 
650 0 4 |a breast tumor 
650 0 4 |a circular ribonucleic acid 
650 0 4 |a circular RNA 
650 0 4 |a diagnosis 
650 0 4 |a diagnostic accuracy 
650 0 4 |a diagnostic value 
650 0 4 |a down regulation 
650 0 4 |a female 
650 0 4 |a Female 
650 0 4 |a gene expression level 
650 0 4 |a genetics 
650 0 4 |a human 
650 0 4 |a Humans 
650 0 4 |a meta analysis 
650 0 4 |a meta-analysis 
650 0 4 |a real time reverse transcription polymerase chain reaction 
650 0 4 |a receiver operating characteristic 
650 0 4 |a RNA, Circular 
650 0 4 |a ROC Curve 
650 0 4 |a sensitivity and specificity 
650 0 4 |a systematic review 
650 0 4 |a tumor marker 
650 0 4 |a upregulation 
700 1 |a Chu, M.  |e author 
700 1 |a Fang, Y.  |e author 
700 1 |a Jin, Y.  |e author 
773 |t Journal of Clinical Laboratory Analysis