Critical role for the lung endothelial nonmuscle myosin light-chain kinase isoform in the severity of inflammatory murine lung injury

Critical role for the lung endothelial nonmuscle myosin light-chain kinase isoform in the severity of inflammatory murine lung injury

Global knockout of the nonmuscle isoform of myosin light-chain kinase (nmMLCK), a primary cellular regulator of cytoskeletal machinery, is strongly protective in preclinical murine models of inflammatory lung injury. The current study was designed to assess the specific contribution of endothelial c...

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Bibliographic Details
Main Authors: Bermudez, T. (Author), Burt, J. (Author), Camp, S.M (Author), Dudek, S.M (Author), Garcia, J.G.N (Author), Hernon, V.R (Author), Hufford, M.K (Author), Kempf, C.L (Author), Sammani, S. (Author), Song, J.H (Author)
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Subjects:
ARDS
MLCK
Online Access:View Fulltext in Publisher

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