In vivo proton magnetic resonance spectroscopy (1H-MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma

• Main Authors: Abdulrahman, F. (Author), Kuo, T.L (Author), Rahmat, K. (Author), Ramli, N. (Author), Ramli, N.M (Author), Sidek, S. (Author)
• Format: Article
• Language: English
• Published: Springer Verlag 2016
• Subjects: adult; Adult; aged; Aged; analogs and derivatives; analysis of variance; Analysis of Variance; Article; aspartic acid; Aspartic Acid; axon; biological marker; Biomarkers; choline; Choline; clinical article; clinical evaluation; comparative study; controlled study; correlation analysis; creatine; Creatine; Cross-Sectional Studies; cross-sectional study; disease classification; female; Female; Glaucoma; Glaucoma, Open-Angle; glutamic acid; Glutamic Acid; glutamine; Glutamine; glycerophosphorylcholine; Hodapp Parrish Anderson classification; human; Humans; in vivo study; Magnetic resonance imaging; Magnetic Resonance Spectroscopy; male; Male; metabolism; metabolite; Metabolites; middle aged; Middle Aged; n acetylaspartic acid; n acetylaspartylglutamic acid; N-acetylaspartate; nerve degeneration; nerve fiber; Nerve Fibers; Neurodegeneration; nuclear magnetic resonance scanner; nuclear magnetic resonance spectroscopy; open angle glaucoma; optic nerve; Optic Nerve; optic radiation; pathology; phosphorylcholine; priority journal; procedures; Proton Magnetic Resonance Spectroscopy; proton nuclear magnetic resonance; Radiation Dosage; radiation dose; single voxel spectroscopy; spectroscopy; Spectroscopy; young adult; Young Adult
• Online Access: View Fulltext in Publisher; View in Scopus

 Objective: To compare the metabolite concentration of optic radiation in glaucoma patients with that of healthy subjects using Proton Magnetic Resonance Spectroscopy (1H-MRS). Methods: 1H-MRS utilising the Single-Voxel Spectroscopy (SVS) technique was performed using a 3.0Tesla MRI on 45 optic radiations (15 from healthy subjects, 15 from mild glaucoma patients, and 15 from severe glaucoma patients). A standardised Volume of Interest (VOI) of 20 × 20 × 20 mm was placed in the region of optic radiation. Mild and severe glaucoma patients were categorised based on the Hodapp–Parrish–Anderson (HPA) classification. Mean and multiple group comparisons for metabolite concentration and metabolite concentration ratio between glaucoma grades and healthy subjects were obtained using one-way ANOVA. Results: The metabolite concentration and metabolite concentration ratio between the optic radiations of glaucoma patients and healthy subjects did not demonstrate any significant difference (p > 0.05). Conclusion: Our findings show no significant alteration of metabolite concentration associated with neurodegeneration that could be measured by single-voxel 1H-MRS in optic radiation among glaucoma patients. Key Points: • Glaucoma disease has a neurodegenerative component. • Metabolite changes have been observed in the neurodegenerative process in the brain. • Using SVS, no metabolite changes in optic radiation were attributed to glaucoma. © 2016, The Author(s).