Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms

Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms

Cardiac action potential (AP) shape and propagation are regulated by several key dynamic factors such as ion channel recovery and intracellular Ca2+ cycling. Experimental methods for manipulating AP electrical dynamics commonly use ion channel inhibitors that lack spatial and temporal specificity. I...

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Bibliographic Details
Main Authors: Biasci, V. (Author), Bub, G. (Author), Campione, M. (Author), Cerbai, E. (Author), Coppini, R. (Author), Ferrantini, C. (Author), Hussaini, S. (Author), Loew, L.M (Author), Luther, S. (Author), Marchal, G.A (Author), Pavone, F.S (Author), Poggesi, C. (Author), Sacconi, L. (Author), Santini, L. (Author)
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
Cardiac alternans
Optogenetics
Ventricular tachycardias
Voltage imaging
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