Attention and executive functions computer training for attention-deficit/hyperactivity disorder (ADHD): results from a randomized, controlled trial

• Main Authors: Bikic, A. (Author), Bilenberg, N. (Author), Christensen, T.Ø (Author), Dalsgaard, S. (Author), Leckman, J.F (Author)
• Format: Article
• Language: English
• Published: Dr. Dietrich Steinkopff Verlag GmbH and Co. KG 2018
• Subjects: ADHD; adolescent; Adolescent; Article; attention; Attention; attention deficit disorder; Attention Deficit Disorder with Hyperactivity; child; Child; child parent relation; clinical trial; cognition; Cognition; cognitive behavioral therapy; Cognitive Behavioral Therapy; Cognitive remediation; Cognitive training; computer assisted therapy; Computer training; continuous performance test; controlled study; Denmark; DSM-IV; executive function; Executive Function; Executive function training; female; Female; human; Humans; major clinical study; male; Male; multicenter study; Non-pharmacological treatment; outcome assessment; Parents; pattern recognition; physiology; procedures; psychology; randomized controlled trial; scanning electron microscopy; Schedule for Affective Disorders and Schizophrenia; school child; single blind procedure; Single-Blind Method; Therapy, Computer-Assisted; treatment outcome; Treatment Outcome; video game; Video Games; working memory
• Online Access: View Fulltext in Publisher

 Multicenter randomized clinical superiority single-blind trial investigated the effect of a computer training program targeting multiple cognitive functions. Seventy children with ADHD, aged 6–13, were randomized to intervention or control group. The intervention group used ACTIVATE™ for 8 weeks and both groups received treatment as usual and were assessed in regard to cognitive functions, symptoms, behavioral and functional outcome measures after 8, 12 and 24 weeks. There was no significant effect on the primary outcome, sustained attention (β = − 0.047; CI − 0.247 to 0.153) or the secondary outcomes [parent-rated ADHD-RS, β = − 0.037; CI (− 0.224 to 0.150); teacher-rated-ADHD-RS, β = 0.093; CI (− 0.107 to 0.294); parent-rated-BRIEF, β = − 0.119; CI (− 0.307 to 0.069); and teacher-rated-BRIEF, β = 0.136; CI (− 0.048 to 0.322)]. This multicenter randomized clinical trial found no significant beneficial effects of cognitive training using the computer program ACTIVATE on the primary or secondary outcome measures in children with ADHD. Nevertheless, our study was likely underpowered to detect small to moderate changes. Trial registration ClinicalTrials.gov: NCT01752530, date of registration: December 10, 2012. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.