The crystal structure and cytotoxicity of centrosymmetric copper(II) complex derived from S-methyldithiocarbazate with isatin

• Main Authors: Crouse, K.A (Author), How, F.N.-F (Author), Manan, M.A.F.A (Author), Rosli, R. (Author), Tahir, M.I.M (Author), Watkin, D.J (Author)
• Format: Article
• Language: English
• Subjects: Centrosymmetric; Copper(II); Dithiocarbazate; MCF-7; Schiff base
• Online Access: View Fulltext in Publisher; View in Scopus
• ISBN: 10741542 (ISSN)
• DOI: 10.1007/s10870-011-0190-8

Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB-231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC 50 value 0.45 μg/mL. The crystal structure of this centrosymmetric Cu(SMISA) 2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. © Springer Science+Business Media, LLC 2011.